Brazil hosts one of the world's most diverse reptilian faunas, with over 800 species distributed across its various biomes. This paper examines the historical development of herpetological research in Brazil, particularly focusing on two pioneering institutions: the Vital Brazil Institute and the Butantan Institute. These centers have been instrumental in both the scientific study of reptiles and the development of antivenoms since the early 20th century. We explore the remarkable morphological adaptations of Brazilian reptiles across different biomes, from the Amazon rainforest to the Caatinga desert, highlighting how these adaptations reflect the country's diverse ecological pressures. This review synthesizes current knowledge while identifying gaps in our understanding of Brazilian herpetofauna.