Abstract: Background/Objectives: Autism Spectrum Disorders (ASD), attention deficit hyperactivity disorder (ADHD), and Tourette Syndrome (TS) are neurodevelopmental disorders (NDD) with overlapping symptoms suggesting a partially shared genetic factor. This study investigates the prevalence of connective tissue-related conditions in individuals with ASD, ADHD, or TS. Methods: A questionnaire was administered to families of 120 individuals with ASD, ADHD, or TS, collecting sociodemographic data and examining 10 types of disorders affecting various organs and systems. Statistical analyses were performed using STATA 16.0, with a significance level set at 5%. Results: Among the 120 cases, 48 had ASD, 36 had ADHD, and 36 had TS. Flat feet were significantly more common in individuals with ASD (52.1%; OR 7.20; p<0.001), ADHD (52.8%; OR 6.73; p=0.001), and TS (38.9%; OR 3.70; p=0.034) compared to controls (13.6%). Hypersensitivity was more frequent in individuals with ASD (56.3%; OR 5.90; p=0.001), ADHD (50.0%; OR 4.11; p=0.011), and TS (58.3%; OR 5.35; p=0.003) compared to controls (18.2%). Myopia and ptosis were more common in ADHD (30.6%). There was a possible trend towards orthodontic device use in TS (OR 3.20; p=0.076). Flat feet and hypersensitivity were also common in fathers (31.0% and 36.4%, respectively), mothers (31.0% and 15.2%), and patients (43.8% and 55%). Conclusions: These results suggest common aetiopathogenetic factors, with connective tissue anomalies potentially underlying different clinical phenotypes. Further studies are warranted.

Abstract: Patellofemoral pain syndrome (PFPS) ranks among the most prevalent factors causing anterior knee pain. Quadriceps exercises such as forward lunges are important to treat PFPS. Aim: We in-vestigated whether there is a muscle activity difference between the vastus medialis oblique (VMO) and vastus lateralis (VL) muscles and the center of pressure (CoP) among three hip posi-tions: hip adduction forward lunge (HADF), hip neutral forward lunge (HNEF), and hip abduc-tion forward lunge (HABF) in healthy subjects. Method: This was a randomized controlled pilot study that included twenty healthy volunteers. CoP was measured using a “Wii Balance Board” from Nintendo and VMO and VL muscle activity were measured via wireless surface electro-myography. Results: CoP outcomes showed significant differences among the three positions in position, sum distance, range, and max distance. VMO and VL muscle activity and the ratio of VMO/VL significantly differed among the three positions. Conclusions: Although VMO and VL muscle activity increased in HADF and HABF, excessive change in CoP occurred in the two posi-tions. The change in the CoP during HADF and HABF may result in valgus, varus, and loading of the knee joint, which may worsen PFPS. The HNEF is recommended for quadriceps strengthening in healthy subjects and PFPS patients.

Abstract: Background/Objectives: Climate change adversely affects some of the fundamental determinants of health, and children are the population group most vulnerable to exposure to environmental risk factors. The main objective of this study was to validate in the Portuguese context three scales to assess attitudes, knowledge and skills on children's environmental health. Methods: A cross-sectional observational study was developed to translate, adapt, and validate the questionnaire consisting of the following three scales: Attitude Scale (SANS_2), knowledge scale (ChEHK-Q), and skills scale (ChEHS-Q). This was carried out in two phases: The translation and adaptation process and the validation process using the classical measure theory and item response theory with undergraduate nursing students. Results: We obtained a valid and reliable questionnaire to measure children's environmental health competence consisting of an attitude scale (α = 0.84), a knowledge scale (Infit = 0.98, Outfit = 0.97, item reliability = 0.98 and people reliability = 0.75) and a skills scale (Infit = 1.00, Outfit = 0.99, item reliability = 0.82 and people reliability = 0.88). The mean score on the attitude scale was 28.15 (5-35) ± 4.61; 14.92 (0-26) ± 4.51 on the knowledge scale, and 42.51 (24-60) ± 6.41 on the skills scale. Conclusions: We found that most Portuguese nursing students have very good pro-environmental attitudes and good knowledge and skills in dealing with children's environmental health. The questionnaire obtained in this study will be useful for comparative studies with other countries and for evaluating the effectiveness of educational interventions.

Abstract: The pervasive presence of per- and polyfluoroalkyl substances (PFAS) in the environment and their persistent nature raise significant concerns regarding their impact on human health. This review delves into the obesogenic potential of PFAS, shedding light on their mechanisms of action, epidemiological correlations with obesity and metabolic disorders, and the challenges faced in regulatory frameworks. PFAS, characterized by their carbon-fluorine chains, are ubiquitous in various consumer products, leading to widespread exposure through ingestion of contaminated food and water. Emerging evidence suggests that PFAS may act as endocrine-disrupting chemicals, interfering with lipid metabolism and hormone functions related to obesity. We examine in vitro, in vivo, human, and in silico studies that explore the interaction of PFAS with peroxisome proliferator-activated receptors (PPARs) and other molecular targets, influencing adipogenesis and lipid homeostasis. Furthermore, the review highlights epidemiological studies investigating the association between maternal PFAS exposure and the risk of obesity in offspring, presenting mixed and inconclusive findings that underscore the complexity of PFAS effects on human health. Presently, there are major challenges in studying PFAS toxicity, including their chemical diversity and the limitations of current regulatory guidelines, potential remediation, and detoxification. This review emphasizes the need for a multidisciplinary approach, combining advanced analytical methods, in silico models, and comprehensive epidemiological studies, to unravel the obesogenic effects of PFAS and inform effective public health strategies.

Abstract: Coughing is a symptom of many respiratory diseases. An increased amount of coughs may signal an (upcoming) health issue, a decreasing amount of coughs may indicate an improved health status. The presence of a cough can be identified by a cough classifier. The cough density fluctuates considerably over the course of a day with a pattern that is highly subject dependent. This paper provides a case study of cough patterns from COPD patients as determined by a stationary semi-automated cough monitor. It clearly demonstrates the variability of cough density over the observation time, its patient specificity and dependence on health status. Furthermore, an earlier established empirical finding of a linear relation between mean and standard deviation of a session's cough count is validated. An alert mechanism incorporating these findings is described.

Abstract:

Suicide is a global phenomenon, with more than 700,000 people worldwide taking their own life yearly. Both natural and human-made disaster may have a detrimental effect on suicidal behaviors both in the short-term and in the long-term. Many studies focused on the acute impact of the COVID-19 pandemic on suicidality. The aim of the study was to analyze demographic and clinical features of subjects accessing the emergency rooms for suicidality during the second epidemic wave of COVID-19 in five emergency departments in Lombardy (Italy). A retrospective chart review was conducted in the five emergency departments for the period 4 June – 31 December 2020, and during the same time lapse in 2019. For all subjects accessing for suicidality, socio-demographic and clinical data were collected and compared between the two years. No differences between the two years were found for sex, triage priority level, history of substance abuse, factor triggering suicidality and discharge diagnosis. During 2020 a greater proportion of subjects did not show any previous mental disorder, however, more subjects were already taking anxiolytic medications before the admission. Among a range of possible risk factors, attempted suicide, depression diagnosis and taking medications before the admission were found to be predictor of admission to psychiatric inpatient units. Characterizing subjects prone to suicidality during the second wave of the COVID-19 pandemic, our study provides hints for mid-term causes of suicidality and possible preventive measures that could be helpful in the course and after massive infectious outbreaks.

Abstract:

Background: In both developed and developing nations, childhood poisoning is a significant source of morbidity. The majority of poisoning incidents involving teenagers happen accidentally and are brought on by liquid intake. Case Presentation: A 6-year-old school-aged child with possible organophosphate pesticide poisoning was sent to the emergency department. At the time of his arrival at the emergency department, the patient's mental condition had already been injured. He had a moderate traumatic brain injury when he entered the emergency room and scored an 9/15 on the Glasgow Coma Scale. His medical examination upon arrival revealed lacrimation, hypersalivation, a dry mouth, and pinpoint pupils. Atropine (0.05 mg/kg) was administered intravenously to him once in the emergency room. In pediatric critical care unit, he received continuous infusions of pralidoxime at a rate of 10 mg/kg/hour for 16 hours after receiving an intravenous infusion of atropine at a rate of 1 mg/kg/hour for the first 4 hours, followed by 2 further atropine infusions at a rate of 1 mg/kg/hour for the next 4 hours. Conclusion: Globally, childhood poisoning is a major cause of hospitalization, disability, and death. Ingesting organophosphates can lead to poisoning in children.

Abstract: Non-typhoidal Salmonella (NTS) infections in poultry, particularly in commercial layer chickens, pose a critical risk to food safety and public health worldwide. NTS bacteria can remain undetected in poultry flocks, contaminating products, and potentially leading to gastroenteritis in humans. This review examines pre-harvest control strategies for NTS in layer chickens, including biosecurity protocols, vaccinations, feed additives, genetic selection, and environmental management. By evaluating these strategies, this review highlights the importance of integrated control measures to limit NTS colonization, reduce antimicrobial resistance, and improve poultry health. This review aims to provide producers, researchers, and policymakers with insights into effective practices to minimize Salmonella contamination and enhance both animal and human health outcomes.

Abstract:

Background and importance: Immunoglobulins, lactoalbumin, lactoperoxidase, casein, lysozyme, lactoferrin, and amylase are just a few of the proteins found in camel milk. Camel milk appears to be safe and effective in enhancing long-term glycemic control and also acts as a facilitator in lowering the insulin demand by 30% for type 1 diabetes mellitus patients, therefore, it can be utilized as an alternative to insulin therapy. Alpha-hydroxyl acids, which are utilized to help exfoliate dead skin cells and enable skin renewal and new cell creation, are more concentrated in camel milk. The two main components of camel milk are lactoferrin and immunoglobulins, which provide the milk with its immune-stimulating qualities. Aims of the study: The goal of this review is to discuss the medicinal, physiological, and nutritional advantages of camel milk for people's health. Methodology: For the purpose of this review article, the author evaluated 56 different published articles. Access to published publications from databases like PubMed, the Scopus database, and the Cochrane database was made possible by using the Google search engine. Discussion: Because the milk of immunized camels contains neutralizing antibodies, it can provide passive immunity to individuals who have SARS-CoV-2. Lactoferrin, the primary iron-attaching protein in camel milk, is effective in preventing the growth of cancer by 56%. Camel milk has a lot of ascorbic acids, which help improve liver function. Conclusion: Camel milk has numerous therapeutic benefits, including antibacterial, anticarcinogenic, antioxidant, anti-hypertensive, and anti-diabetic properties.

Abstract: Wearable devices gain increasing attention for use in multifunctional applications related to health monitoring, particularly in research of the circadian rhythms of cognitive functions and metabolic processes. In this comprehensive review, we encompass how wearables can be used to study circadian rhythms in health and disease. We highlight the importance of these rhythms as markers of health and well-being, and as potential predictors for health outcomes. We focus on the use of wearable technologies in sleep research, circadian medicine, and chronomedicine beyond the -ircadian domain, with an emphasis on actigraphy as a validated tool for monitoring sleep, activity, and light exposure. We discuss various mathematical methods currently used to analyze actigraphic data, such as parametric and non-parametric approaches, applied to quantify circadian and non-circadian variability. We also introduce novel actigraphy-derived markers, which can be used as personalized proxies of health status, assisting in discriminating between health and disease, offering insights into neurobehavioral and metabolic status. We discuss how lifestyle factors such as physical activity and light exposure can modulate brain functions and metabolic health. We emphasize the importance of establishing reference standards for actigraphic measures to further refine data interpretation and improve clinical and research outcomes. The review calls for further research to refine existing tools and methods, deepen our understanding of circadian health, and develop personalized healthcare strategies.