Obesity is the most prevalent nutritional disorder in the world and is considered a major health issue due to its association with the development of cardiovascular and chronic-degenerative diseases. Oxidative stress is a distinctive feature of obesity promoted by an imbalance between oxidant and antioxidant systems in the body leading to excessive reactive oxygen species (ROS) production. Chronic oxidative stress adversely alters the structure and physiological function of lipids, proteins and DNA, which ultimately favors the development of obesity-related diseases. The main strategy to reverse the oxidative stress associated with obesity is the loss of body fat through the implementation of various dietary strategies that include antioxidant-rich foods. Lifestyle changes, such as increasing physical activity, has also shown to reduce ROS generation and improve systemic antioxidant capacity in overweight and obese subjects. This review provides an overview of how antioxidants, both endogenous and exogenous, may participate during obesity in the decrease of body fat and associated metabolic disturbances, proposing them as an important therapeutic strategy in addition to physical activity and dietary interventions for the management of obesity.