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Aftab, A., Sil, S., Nath, S. et al. Intrinsic Disorder and Other Malleable Arsenals of Evolved Protein Multifunctionality. J Mol Evol (2024). https://doi.org/10.1007/s00239-024-10196-7
Aftab, A., Sil, S., Nath, S. et al. Intrinsic Disorder and Other Malleable Arsenals of Evolved Protein Multifunctionality. J Mol Evol (2024). https://doi.org/10.1007/s00239-024-10196-7
Aftab, A., Sil, S., Nath, S. et al. Intrinsic Disorder and Other Malleable Arsenals of Evolved Protein Multifunctionality. J Mol Evol (2024). https://doi.org/10.1007/s00239-024-10196-7
Aftab, A., Sil, S., Nath, S. et al. Intrinsic Disorder and Other Malleable Arsenals of Evolved Protein Multifunctionality. J Mol Evol (2024). https://doi.org/10.1007/s00239-024-10196-7
Abstract
The evolution of human society over the course of decades and centuries has led toan ever-increasingly complex modern life, one of the hallmark of which is the need for multi-tasking, both individually and collectively. Does this macroscopic evolution of the human societal dynamics have an empirical mapping to the microscopic evolution of the functionalmolecular units within cells and their manifold cross-talks? The relatively new wealth of knowledge coming from recent research on protein intrinsic disorder, fold-switching, domain shuffling, gene duplication, and other aspects has given us new insights into the relationship between protein structure and function. This has led to a paradigm shift in protein science, clearly diverging from the traditional idea of 'one sequence – one structure – one function' to a more complex understanding of protein functionality. This paradigm shift has caused scientists to delve deeper into the subject, exploring the philosophical as well as the scientific basis of evolved protein multi-functionality, expressed by various evolutionary toys and tools to fit the cumulative multi-functional requirements within proteins. This commentary covers thedifferent evolutionary arsenals to achieve the growing multi-functionalityand attempts to connect intrinsic disorder in proteins as probably the sharpest weapon of all.
Keywords
Protein multi-functionality; Intrinsically Disordered Proteins; Gene duplication; Domain Shuffling; Protein moonlighting
Subject
Biology and Life Sciences, Biophysics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
