Concept Paper
Version 2
Preserved in Portico This version is not peer-reviewed
A CSF Shunt System for Liquorpheresis and CSF Replacement
Version 2
: Received: 20 December 2016 / Approved: 21 December 2016 / Online: 21 December 2016 (10:12:13 CET)
Version 5 : Received: 30 January 2017 / Approved: 30 January 2017 / Online: 30 January 2017 (14:22:03 CET)
Version 5 : Received: 30 January 2017 / Approved: 30 January 2017 / Online: 30 January 2017 (14:22:03 CET)
How to cite: González, M. M. A CSF Shunt System for Liquorpheresis and CSF Replacement. Preprints 2016, 2016120105. https://doi.org/10.20944/preprints201612.0105.v2 González, M. M. A CSF Shunt System for Liquorpheresis and CSF Replacement. Preprints 2016, 2016120105. https://doi.org/10.20944/preprints201612.0105.v2
Abstract
Liquorpheresis (CSF filtration) comprises a therapeutical approach that has been proposed to treat several neurological conditions where antibodies, inflammatory mediators or abnormal peptides are the cause or play an important role in the pathogenesis of the disease. Continuous or intermittent CSF replacement may be an alternative approach not explored so far.Here, we review previous experiences in the use of liquorpheresis in autoimmune and degenerative neurological diseases. Then we describe a bidirectional CSF shunt system allowing portable liquorpheresis. Alternatively, CSF can be replaced with artificial cerebrospinal fluid. Both options would lead to mechanical dilution of the patient’s CSF.
Keywords
csf; shunt; filtration; neurodegenerative; neuroimmunology; alzheimer; parkinson; guillain-barre; device; ventriculo-peritoneal shunt
Subject
Medicine and Pharmacology, Neuroscience and Neurology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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