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Article
Synthesis and Anti-Tuberculosis Activity of Olivacine and Oxygenated Derivatives
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Submitted:
30 April 2018
Posted:
02 May 2018
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Abstract
The tetracyclic pyrido[4,3-b]carbazole olivacine and four of its oxygenated derivatives have been synthesized by a late-stage palladium-catalyzed Heck-type cyclization of the pyrrole ring as key step. In a test for inhibition of the growth of Mycobacterium tuberculosis 9-methoxyolivacine showed the most significant anti-TB activity with an MIC90 value of 1.5 μM.
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Subject: Chemistry and Materials Science - Organic Chemistry
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