Review
Version 1
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Annexins in Translational Research: Hidden Treasures to be Found
Version 1
: Received: 22 May 2018 / Approved: 23 May 2018 / Online: 23 May 2018 (08:19:42 CEST)
How to cite: Schloer, S.; Pajonczyk, D.; Rescher, U. Annexins in Translational Research: Hidden Treasures to be Found. Preprints 2018, 2018050319. https://doi.org/10.20944/preprints201805.0319.v1 Schloer, S.; Pajonczyk, D.; Rescher, U. Annexins in Translational Research: Hidden Treasures to be Found. Preprints 2018, 2018050319. https://doi.org/10.20944/preprints201805.0319.v1
Abstract
The vertebrate annexin superfamily (AnxA) consists of 12 calcium (Ca2+) and phospholipid binding proteins which share a high structural homology. In keeping with this hallmark feature, annexins have been implicated in the Ca2+-controlled regulation of membrane events. In this review, we discuss several themes of potential therapeutic value, namely the regulation of the immune response and the control of tissue homeostasis, that repeatedly surface in the annexin action profile. Our aim is to identify and discuss those annexin properties which might be exploited from a translational science and specifically clinical point of view.
Keywords
annexins; inflammation; wound healing; drug target; translational research
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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