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Quantum Modeling: A Bridge between the Pumping and Signaling Functions of the Na/K – ATPase
Version 1
: Received: 11 July 2018 / Approved: 12 July 2018 / Online: 12 July 2018 (05:26:21 CEST)
A peer-reviewed article of this Preprint also exists.
Wang, W.; Shapiro, J.I. Quantum Modeling: A Bridge between the Pumping and Signaling Functions of Na/K-ATPase. Int. J. Mol. Sci. 2018, 19, 2347. Wang, W.; Shapiro, J.I. Quantum Modeling: A Bridge between the Pumping and Signaling Functions of Na/K-ATPase. Int. J. Mol. Sci. 2018, 19, 2347.
Abstract
Although the signaling function of Na/K ATPase is been studied for decades, the chasm between the pumping function and the signaling function of Na/K – ATPase is still an open issue. This article explores the relationship between ion pumping and signaling with attention to the amplification of oxidants through this signaling function. Starting with some experimental observations published by our laboratories and others, we develop some predictions regarding cellular oxidant stress.
Keywords
Na/K – ATPase; Markov chain; master equation; Src; oxidant stress; reactive oxygen species; aging
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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