Currently, there isn’t much written about the empirical psychological well-being of the atheist community in Puerto Rico and Latin America. The objective of the present study is to analyze if there are statistically significant differences in the levels of life satisfaction and psychological flourishing between believers of God and self-identified atheists. For this purpose, a sample of 821 participants (415 believers and 406 atheists) ranging from the ages of 19 to 85 years were selected. The results sustain that, there is a slight average difference regarding life satisfaction between these groups; however, the difference is not substantial to ensure that believers have a better quality of life and life satisfaction than atheists. At the same time, no statistically significant differences were found in the means of psychological flourishing. Both believers and atheists exhibit high levels of life satisfaction and psychological flourishing. This study provides empirical evidence to demystify certain traditional assumptions about the supremacy of religious beliefs over secular convictions. We hope that these findings create social awareness and could be used as a basis for future researches concerning the population of non-believers.