Version 1
: Received: 12 January 2020 / Approved: 12 January 2020 / Online: 12 January 2020 (16:58:35 CET)
How to cite:
Li, W. Inter-Molecular Electrostatic Interactions Stabilizing the Structure of the PD-1/PD-L1 Axis: A Structural Evolutionary Perspective. Preprints2020, 2020010130. https://doi.org/10.20944/preprints202001.0130.v1
Li, W. Inter-Molecular Electrostatic Interactions Stabilizing the Structure of the PD-1/PD-L1 Axis: A Structural Evolutionary Perspective. Preprints 2020, 2020010130. https://doi.org/10.20944/preprints202001.0130.v1
Li, W. Inter-Molecular Electrostatic Interactions Stabilizing the Structure of the PD-1/PD-L1 Axis: A Structural Evolutionary Perspective. Preprints2020, 2020010130. https://doi.org/10.20944/preprints202001.0130.v1
APA Style
Li, W. (2020). Inter-Molecular Electrostatic Interactions Stabilizing the Structure of the PD-1/PD-L1 Axis: A Structural Evolutionary Perspective. Preprints. https://doi.org/10.20944/preprints202001.0130.v1
Chicago/Turabian Style
Li, W. 2020 "Inter-Molecular Electrostatic Interactions Stabilizing the Structure of the PD-1/PD-L1 Axis: A Structural Evolutionary Perspective" Preprints. https://doi.org/10.20944/preprints202001.0130.v1
Abstract
PD-1/PD-L1 axis is one key therapeutic target against tumor cell immune escape. Structurally essential to the PD-1/PD-L1-linked immune escape is the binding interface of the PD-1/PD-L1 complex structure. Incorporating currently available PD-1/PD-L1-related experimental structures, this article unveils two sets of experimentally observed inter-molecular electrostatic interactions which stabilize the binding interface of the PD-1/PD-L1 complex structure. For the first time, this article proposes an evolutionary structural hypothesis that, as a result of natural selection, PD-1 is able to genetically mutate itself to structurally disrupt the PD-1/PD-L1 axis towards the restoration of T cell-mediated anti-tumor immunity.
Biology and Life Sciences, Biology and Biotechnology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.