Preprint

Communication

Serological Test is an Efficient Supplement for Detecting RNA to Confirm SARS-CoV-2 Infection

Altmetrics

Downloads

2407

Views

5040

Comments

Ning-Shao Xia^*

Gui-Qiang Wang,Wen-Feng Gong

Ning-Shao Xia^*

Gui-Qiang Wang,Wen-Feng Gong

This version is not peer-reviewed

This preprints belongs to the Collection

Preprints on COVID-19 and SARS-CoV-2

Submitted:

05 April 2020

Posted:

06 April 2020

You are already at the latest version

Alerts

Abstract

To date, viral RNA detection is almost the only way to confirm SARS-CoV-2infectionin practice.However, variousreasons can cause low sensitivity for RNA detection, and thisposes aserious challenge to disease control. We tested the performance of detecting total antibody(Ab) and IgM levels in serum by the methods of chemiluminescence, enzyme-linked immunosorbent assay (ELISA), and colloidal golddetection. The datashowed that the sensitivity and specificity for detecting total Ab and IgM levels were high by all three methods, and the sensitivity was higher for detecting total Ab than for detecting IgM. Evidence from studieshas shown thatviral RNA testingcombinedwith serological testing could increase the diagnostic sensitivity while maintaining a high specificity. Specific serology testsfor SARS-CoV-2 havegreat value for clinical practice and public health.

Keywords:

Subject: Biology and Life Sciences - Virology

Copyright: This open access article is published under a Creative Commons CC BY 4.0 license, which permit the free download, distribution, and reuse, provided that the author and preprint are cited in any reuse.