Version 1
: Received: 13 March 2020 / Approved: 15 March 2020 / Online: 15 March 2020 (14:39:19 CET)
How to cite:
Wu, J.; Ping, Z. Association of COVID-19 Disease Severity with Transmission Routes and Suggested Changes to Community Guidelines. Preprints2020, 2020030246. https://doi.org/10.20944/preprints202003.0246.v1
Wu, J.; Ping, Z. Association of COVID-19 Disease Severity with Transmission Routes and Suggested Changes to Community Guidelines. Preprints 2020, 2020030246. https://doi.org/10.20944/preprints202003.0246.v1
Wu, J.; Ping, Z. Association of COVID-19 Disease Severity with Transmission Routes and Suggested Changes to Community Guidelines. Preprints2020, 2020030246. https://doi.org/10.20944/preprints202003.0246.v1
APA Style
Wu, J., & Ping, Z. (2020). Association of COVID-19 Disease Severity with Transmission Routes and Suggested Changes to Community Guidelines. Preprints. https://doi.org/10.20944/preprints202003.0246.v1
Chicago/Turabian Style
Wu, J. and Zha Ping. 2020 "Association of COVID-19 Disease Severity with Transmission Routes and Suggested Changes to Community Guidelines" Preprints. https://doi.org/10.20944/preprints202003.0246.v1
Abstract
In the war against theCOVID-19pandemic, the world is experiencing severe resource constraints. Although transmission routes are well understood, wesuspect that they cause different disease consequences. We evaluate them in different forms to understand how they affect infectionrates and disease severity. In determining how they affect disease outcome, we evaluated target tissue vulnerability, functional role, defense mechanisms, viral concentration, infection vicinity to target vital tissue, and host factors. We found that direct lung infection is the most lethal transmission route followed by bronchi infection. Transmissions by physical contacts, foods, and blood by low viral concentration (as expected in normal human activities) pose loweror much lowerrisks unless the infection is followed bysubsequent lung exposures. After adding transmission route, treatment timings, and improper treatments into the list of known risk factors, we found that death rate and disability rate for young or healthy persons are nearly zero. We show that population based medical model improperly shiftsnominal death rate from few vulnerable people to the population resulting in unnecessary population panic, and such panic is responsible for shutting down human activities and the world economy. Finally, we examined limitations in population-based mitigating measures and proposed for governmental and private adoption community guidelines, which are mainly to enable vulnerable people avoidexposures, prevent non-vulnerable people from serving as viral transmitters, get rid of high-risk exposuremodesin working environment, improve safety for people inbuses, ships and planes, and reduce death and disability rates for infected people.
Medicine and Pharmacology, Pharmacology and Toxicology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The commenter has declared there is no conflict of interests.
Comment:
I agree that transmission route is important.
See the findings tab of this doc: https://docs.google.com/spreadsheets/d/15ml1IWPy_rdaPxVMSFmU1vCiG7bsui8tRHFthm5Yo6c/edit#gid=1078385797 Staff safety section, papers listed as "dose effect"
Commenter:
The commenter has declared there is no conflict of interests.
See the findings tab of this doc: https://docs.google.com/spreadsheets/d/15ml1IWPy_rdaPxVMSFmU1vCiG7bsui8tRHFthm5Yo6c/edit#gid=1078385797
Staff safety section, papers listed as "dose effect"
You could also consider secondary prophylaxis:
https://docs.google.com/document/d/1q5IH2hGjjdPi-vcs4zOBlArgFJ9iSDdZVoceevUPI9c/