Preprint
Review
The Straight Dope: A Systematic Review of Neuroimaging and Acute Cannabis Exposure in Age-of-Risk for Psychosis
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This version is not peer-reviewed
Submitted:
20 April 2020
Posted:
21 April 2020
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Abstract
Acute exposure to cannabis has been associated with an array of cognitive alterations, increased risk for neuropsychiatric illness, and other neuropsychiatric sequelae including the emergence of acute psychotic symptoms. However, the mechanisms by which cannabis exposure induces these behavioral and clinical phenotypes remain disputed. To this end, neuroimaging can be a powerful technique to non-invasively study the impact of cannabis exposure on brain structure and function in both humans and animal models. The purpose of the present review is to: 1) provide an update on the findings of pharmacological neuroimaging studies examining the effects of cannabinoids and 2) focus the discussion on studies that examine the sensitive window for the emergence of psychosis. Curren literature indicates that cannabis exposure has varied effects on the brain, with the principal compounds in cannabis (delta-9-tetrahydrocannabinol and cannabidiol) both increasing and decreasing activity in various areas. There are gaps in the literature, especially regarding sex-dependent responses and long-term effects of chronic exposure.
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Subject: Biology and Life Sciences - Neuroscience and Neurology
Copyright: This open access article is published under a Creative Commons CC BY 4.0 license, which permit the free download, distribution, and reuse, provided that the author and preprint are cited in any reuse.
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