Preprint
Communication
SARS-CoV-2 Virion Stabilization by Zn Binding
Altmetrics
Downloads
694
Views
539
Comments
1
This version is not peer-reviewed
Preprints on COVID-19 and SARS-CoV-2
Submitted:
09 August 2020
Posted:
09 August 2020
You are already at the latest version
Alerts
Abstract
Zinc plays a crucial role in the process of virion maturation inside the host cell. The accessory Cys-rich proteins expressed in SARS-CoV-2 by genes ORF7a and ORF8 are likely involved in zinc binding and in interactions with cellular antigens activated by extensive disulfide bonds. In this report we provide a proof of concept for the feasibility of a structural study of orf7a and orf8 proteins. A conceivable hypothesis is that lack of cellular zinc, or substitution thereof, might lead to a significant slowing down of viral maturation.
Keywords:
Subject: Biology and Life Sciences - Biophysics
Copyright: This open access article is published under a Creative Commons CC BY 4.0 license, which permit the free download, distribution, and reuse, provided that the author and preprint are cited in any reuse.
MDPI Initiatives
Important Links
© 2024 MDPI (Basel, Switzerland) unless otherwise stated