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SARS-CoV2 Envelope Protein: Non-Synonymous Mutations and Its Consequences

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Sk Sarif Hassan^*,Pabitra Pal Choudhury,Bidyut Roy

This version is not peer-reviewed

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Preprints on COVID-19 and SARS-CoV-2

Submitted:

07 June 2020

Posted:

07 June 2020

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Abstract

In the NCBI database, as on June 6, 2020, total number of available complete genome sequences of SARS-CoV2 across the world is 3617. The envelope protein of SARS-CoV2 possesses several non-synonymous mutations over the transmembrane domain and (C)-terminus in 0.414\% of these 3617 genomes. The C-terminus motif DLLV has been changed to DFLV and YLLV in the proteins QJR88103 (Australia: Victoria) and QKI36831 (China: Guangzhou) respectively, which might affect the binding of this motif with the host protein PALS1.

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Subject: Biology and Life Sciences - Virology

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