Version 1
: Received: 21 October 2020 / Approved: 23 October 2020 / Online: 23 October 2020 (10:36:07 CEST)
How to cite:
Sharma, S.; Dutt, M.; Sharma, N.; Dharavath, R. N.; Kaur, T. Methylphenidate and Alprazolam Co-Abuse: Drug-DNA Interactions. Preprints2020, 2020100481. https://doi.org/10.20944/preprints202010.0481.v1
Sharma, S.; Dutt, M.; Sharma, N.; Dharavath, R. N.; Kaur, T. Methylphenidate and Alprazolam Co-Abuse: Drug-DNA Interactions. Preprints 2020, 2020100481. https://doi.org/10.20944/preprints202010.0481.v1
Sharma, S.; Dutt, M.; Sharma, N.; Dharavath, R. N.; Kaur, T. Methylphenidate and Alprazolam Co-Abuse: Drug-DNA Interactions. Preprints2020, 2020100481. https://doi.org/10.20944/preprints202010.0481.v1
APA Style
Sharma, S., Dutt, M., Sharma, N., Dharavath, R. N., & Kaur, T. (2020). Methylphenidate and Alprazolam Co-Abuse: Drug-DNA Interactions. Preprints. https://doi.org/10.20944/preprints202010.0481.v1
Chicago/Turabian Style
Sharma, S., Ravinder Naik Dharavath and Tanzeer Kaur. 2020 "Methylphenidate and Alprazolam Co-Abuse: Drug-DNA Interactions" Preprints. https://doi.org/10.20944/preprints202010.0481.v1
Abstract
Drug abuse is a major issue worldwide. Methylphenidate (MPH) and alprazolam (ALZ) are commonly prescribed drugs for the treatment of ADHD and anxiety disorders, respectively. The limited studies suggest that abusers primarily use benzodiazepines to counteract adverse effects associated with methylphenidate usage. The main aim of this study was to investigate the interaction of drugs with DNA using spectroscopic methods. Female Wistar rats were administered with MPH (10, 20, 40 mg/kg) and ALZ (5, 10, 20 mg/kg) alone and in combination for a period of 28 days. The FT-IR and UV results reveal some spectral changes in a dose-dependent manner, which indicates interactions of drugs with DNA. Thus, the changes in spectral peaks provide some insight into the mechanism of the interaction of drugs with DNA.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.