Review
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Transmembrane 163 (TMEM163) Protein: A New Member of the Zinc Efflux Transporter Family
Version 1
: Received: 20 December 2020 / Approved: 21 December 2020 / Online: 21 December 2020 (10:46:22 CET)
A peer-reviewed article of this Preprint also exists.
Styrpejko, D.J.; Cuajungco, M.P. Transmembrane 163 (TMEM163) Protein: A New Member of the Zinc Efflux Transporter Family. Biomedicines 2021, 9, 220. Styrpejko, D.J.; Cuajungco, M.P. Transmembrane 163 (TMEM163) Protein: A New Member of the Zinc Efflux Transporter Family. Biomedicines 2021, 9, 220.
Abstract
A growing body of evidence continues to demonstrate the vital roles that zinc and its transporters play on human health. The solute carrier (SLC) 30 and 39 families, with ten and fourteen members, respectively, control zinc transport in cells. TMEM163, a recently characterized zinc transporter, has similar characteristics in both structure and function to the SLC30 family. This review examines recent data that reveal TMEM163 to be a zinc efflux transporter and a new member of the cation diffusion facilitator (CDF) family of mammalian zinc transporter (ZNT) proteins. It also discusses reports that implicate TMEM163 in various human diseases.
Keywords
zinc; cation diffusion facilitator; zinc transporter; SV31
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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