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Version 1
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Calcium Channels in Retinal Function and Disease
Version 1
: Received: 21 January 2021 / Approved: 25 January 2021 / Online: 25 January 2021 (10:09:55 CET)
How to cite: Williams, B.; Maddox, W.; Lee, A. Calcium Channels in Retinal Function and Disease. Preprints 2021, 2021010466. https://doi.org/10.20944/preprints202101.0466.v1 Williams, B.; Maddox, W.; Lee, A. Calcium Channels in Retinal Function and Disease. Preprints 2021, 2021010466. https://doi.org/10.20944/preprints202101.0466.v1
Abstract
Voltage-gated Ca2+ (Cav) channels play pivotal roles in regulating gene transcription, neuronal excitability, and neurotransmitter release. In order to meet the spatial and temporal demands of visual signaling, Cav channels exhibit unusual properties in the retina compared to their counterparts in other areas of the nervous system. Here, we review current concepts regarding the specific subtypes of Cav channels expressed in the retina, their intrinsic properties and forms of modulation, and how their dysregulation could lead to retinal disease.
Keywords
ribbon synapse; photoreceptor; Ca2+; neurotransmitter release; ion channel
Subject
Medicine and Pharmacology, Ophthalmology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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