Preprint
Hypothesis
Autoimmune Thrombotic Thrombocytopathy Associated with COVID-19 Infection or Vaccination: Learning from Heparin-induced Thrombocytopenia
This version is not peer-reviewed.
Submitted:
08 April 2021
Posted:
09 April 2021
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Abstract
Prothrombotic thrombocytopathy mimicking heparin-induced thrombocytopenia has been observed in patients with severe COVID-19 and after immunisation with the Vaxzevria vaccine. Herein, we discuss the possible pathogenesis of this disorder focusing on the possible involvement of anti-platelet factor 4 (PFA) autoantibodies.
Keywords:
COVID-19
; vaccine
; heparin
; thrombocytopenia
; thrombosis
; platelet
; endothelial cell
; autoimmunity
; proteoglycan
; B cell
; coagulation
Preprints on COVID-19 and SARS-CoV-2
Copyright: This open access article is published under a Creative Commons CC BY 4.0 license, which permit the free download, distribution, and reuse, provided that the author and preprint are cited in any reuse.
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