Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Immunotherapeutic Potential of m6A-Modifiers in Controlling Acute Myeloid Leukemia

Version 1 : Received: 8 May 2021 / Approved: 10 May 2021 / Online: 10 May 2021 (13:53:12 CEST)

A peer-reviewed article of this Preprint also exists.

Kumar, S.; Nagpal, R.; Kumar, A.; Ashraf, M.U.; Bae, Y.-S. Immunotherapeutic Potential of m6A-Modifiers and microRNAs in Controlling Acute Myeloid Leukaemia. Biomedicines 2021, 9, 690. Kumar, S.; Nagpal, R.; Kumar, A.; Ashraf, M.U.; Bae, Y.-S. Immunotherapeutic Potential of m6A-Modifiers and microRNAs in Controlling Acute Myeloid Leukaemia. Biomedicines 2021, 9, 690.

Abstract

Epigenetic alterations have contributed greatly to human carcinogenesis. Conventional epigenetic studies have been predominantly focused on DNA methylation, histone modifications and chromatin remodelling. However, recently, RNA modification (m6A-methylation) also termed ‘epitranscriptomics’ has emerged as a new layer of epigenetic regulation due to its diverse role in various biological processes. In this review, we have summarized the therapeutic potential of m6A-modifiers in controlling haematological disorders especially acute myeloid leukemia (AML). It is a type of blood cancer affecting specific subsets of blood-forming hematopoietic stem/progenitor cells (HSPCs) which proliferate rapidly and acquire self-renewable capacities with impaired terminal cell-differentiation and apoptosis leading to abnormal accumulation of white blood cells, and thus an alternative therapeutic approach is required urgently. Here, we have described how RNA m6A-modification machineries EEE (Editor/writer: Mettl3, Mettl14; Eraser/remover: FTO, ALKBH5 and Effector/reader: YTHDF-1/2) could be reformed into potential druggable candidate or as RNA modifying drug (RMD) to treat leukemia. Moreover, we have shed-light on the role of microRNA and suppressor of cytokine signalling (SOCS/CISH) in increasing anti-tumor immunity towards leukemia. We anticipate, our investigation will provide a fundamental knowledge in nurturing the potential of RNA modifiers in discovering novel therapeutics or immunotherapeutic procedures.

Keywords

Epitranscriptomics, acute myeloid leukemia, microRNA, CISH, Immunotherapeutics.

Subject

Biology and Life Sciences, Immunology and Microbiology

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