Version 1
: Received: 4 August 2021 / Approved: 5 August 2021 / Online: 5 August 2021 (10:45:07 CEST)
Version 2
: Received: 7 September 2021 / Approved: 7 September 2021 / Online: 7 September 2021 (11:57:23 CEST)
How to cite:
Williams, W. A.; Denslow, A. J.; Radulovic, P. W.; Denmark, D. J.; Mohapatra, S. S. A Computational Method Involving Surface Area to Volume Ratio to Estimate Inorganic Nanoparticle Efficacy. Preprints2021, 2021080138. https://doi.org/10.20944/preprints202108.0138.v1
Williams, W. A.; Denslow, A. J.; Radulovic, P. W.; Denmark, D. J.; Mohapatra, S. S. A Computational Method Involving Surface Area to Volume Ratio to Estimate Inorganic Nanoparticle Efficacy. Preprints 2021, 2021080138. https://doi.org/10.20944/preprints202108.0138.v1
Williams, W. A.; Denslow, A. J.; Radulovic, P. W.; Denmark, D. J.; Mohapatra, S. S. A Computational Method Involving Surface Area to Volume Ratio to Estimate Inorganic Nanoparticle Efficacy. Preprints2021, 2021080138. https://doi.org/10.20944/preprints202108.0138.v1
APA Style
Williams, W. A., Denslow, A. J., Radulovic, P. W., Denmark, D. J., & Mohapatra, S. S. (2021). A Computational Method Involving Surface Area to Volume Ratio to Estimate Inorganic Nanoparticle Efficacy. Preprints. https://doi.org/10.20944/preprints202108.0138.v1
Chicago/Turabian Style
Williams, W. A., Daniel J. Denmark and Shyam S. Mohapatra. 2021 "A Computational Method Involving Surface Area to Volume Ratio to Estimate Inorganic Nanoparticle Efficacy" Preprints. https://doi.org/10.20944/preprints202108.0138.v1
Abstract
Inorganic nanoparticles are utilized for therapeutic, diagnostic, or theranostic purposes and the latter involve simultaneous sensing, imaging, or tracking of drug delivery. Further, these nanoparticles differ in their morphologies, which affect outcomes such as the effectiveness of hyperthermia, induction, drug loading, circulation time by escaping the body's immune system, imaging modality clarity, and biosensing. However, design of these theranostics is limited by the lack of a method to predict their therapeutic efficacy. Herein, we report a computational approach involving the surface area (SA) to volume (V) ratios (SA:V), which can help predict the efficacy of the inorganic nanoparticles. The approach comprises a coding platform for the comparator pro-gram and uses a Python 3 on a Windows 10 operating system. Analyses of 22 polyhedral morphologies that inorganic nanoparticles could assume ex silico showed that only particular concave morphologies in this size regime are more productive over the standard sizes. Our results provide a method that can aid in the predicting efficacy of inorganic nanoparticles with certain morphology.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
