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What We Know About Kininogen Structure – Importance for Function and Perspectives from Cryo-EM

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A peer-reviewed article of this preprint also exists.

Michal Błażej Ponczek^*

This version is not peer-reviewed

Submitted:

30 October 2021

Posted:

01 November 2021

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Abstract

Kininogens are multidomain glycoproteins found in the blood of most vertebrates. They are important in the blood coagulation cascade pathways - in intrinsic pathway activation leading to thrombin generation partially independently from tissue factor dependent extrinsic pathway, connecting blood coagulation with the kallikrein-kinin system. Nothing is known about the shape on atomic level therefore the endeavor to obtain the good-quality spatial structure of kininogens is important for a better understanding of their role in disease and treatment. Application of cryo-EM is important for solving the spatial structure of kininogens, drawing new frontiers in understanding the function and opening new pathways for drug development.

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Subject: Biology and Life Sciences - Biochemistry and Molecular Biology

Copyright: This open access article is published under a Creative Commons CC BY 4.0 license, which permit the free download, distribution, and reuse, provided that the author and preprint are cited in any reuse.