Review
Version 1
Preserved in Portico This version is not peer-reviewed
Review and Comparison of Antimicrobial Resistance Gene Databases
Version 1
: Received: 16 February 2022 / Approved: 17 February 2022 / Online: 17 February 2022 (04:52:10 CET)
A peer-reviewed article of this Preprint also exists.
Papp, M.; Solymosi, N. Review and Comparison of Antimicrobial Resistance Gene Databases. Antibiotics 2022, 11, 339. Papp, M.; Solymosi, N. Review and Comparison of Antimicrobial Resistance Gene Databases. Antibiotics 2022, 11, 339.
Abstract
As the prevalence of antimicrobial resistance genes is increasing in microbes, we are facing the return of the preantibiotic era. Consecutively, the number of studies concerning antibiotic resistance and its spread in the environment is rapidly growing. Next generation sequencing technologies are widespread used in many areas of biological research and antibiotic resistance is no exception. For the rapid annotation of whole genome sequencing and metagenomic results considering antibiotic resistance, several tools and data resources were developed. These databases, however can differ fundamentally in the number and type of genes and resistance determinants they comprise. Furthermore, the annotation structure and metadata stored in these resources can also contribute to their differences. Several previous reviews were published on the tools and databases of resistance gene annotation, however, to our knowledge, no previous review focused solely and in depth on the differences in the databases. In this review, we compare the most well-known and widely used antibiotic resistance gene databases based on their structure and content. We believe that this knowledge is fundamental for selecting the most appropriate database for a research question and for the development of new tools and resources of resistance gene annotation.
Keywords
antibiotic resistance genes; antibiotic resistance gene database; annotation of antibiotic resistance genes
Subject
Biology and Life Sciences, Immunology and Microbiology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comments (0)
We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.
Leave a public commentSend a private comment to the author(s)
* All users must log in before leaving a comment