Review
Version 1
Preserved in Portico This version is not peer-reviewed
Biotechnology, Bioengineering and Applications of Bacillus Nattokinase
Version 1
: Received: 29 June 2022 / Approved: 29 June 2022 / Online: 29 June 2022 (09:39:07 CEST)
A peer-reviewed article of this Preprint also exists.
Yuan, L.; Liangqi, C.; Xiyu, T.; Jinyao, L. Biotechnology, Bioengineering and Applications of Bacillus Nattokinase. Biomolecules 2022, 12, 980. Yuan, L.; Liangqi, C.; Xiyu, T.; Jinyao, L. Biotechnology, Bioengineering and Applications of Bacillus Nattokinase. Biomolecules 2022, 12, 980.
Abstract
Thrombosis has threatened human health in past decades. Bacillus nattokinase is a potential thrombolytic drug without side-effect and low cost and has been introduced into the consumer market as a functional food or dietary supplement. This review firstly summarizes the biodiversity sources and fermentation process of nattokinase, and systematically expounds the structure, cata-lytic mechanism and enzymatic properties of nattokinase; In view of the problems of low fermen-tation yield, insufficient activity and stability of nattokinase, this review discusses the heterologous expression of nattokinase in different microbial hosts, and summarizes the protein and genetic en-gineering progress of nattokinase-producing strains; Finally, this review summarizes the clinical application of nattokinase.
Keywords
Bacillus nattokinase; Physiological and biochemical characteristics; Molecular structure; Molecular modifcation; Functional food and clinical application
Subject
Biology and Life Sciences, Biology and Biotechnology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comments (0)
We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.
Leave a public commentSend a private comment to the author(s)
* All users must log in before leaving a comment