Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Homologous or Heterologous COVID-19 Boosters Regimens Significantly Impact Sero-neutralization of SARS-CoV-2 Virus and Variants

Version 1 : Received: 7 July 2022 / Approved: 12 July 2022 / Online: 12 July 2022 (07:43:56 CEST)

A peer-reviewed article of this Preprint also exists.

Buathong, R.; Hunsawong, T.; Wacharapluesadee, S.; Guharat, S.; Jirapipatt, R.; Ninwattana, S.; Thippamom, N.; Jitsatja, A.; Jones, A.R.; Rungrojchareonkit, K.; Lohachanakul, J.; Suthangkornkul, R.; Tayong, K.; Klungthong, C.; Fernandez, S.; Putcharoen, O. Homologous or Heterologous COVID-19 Booster Regimens Significantly Impact Sero-Neutralization of SARS-CoV-2 Virus and Its Variants. Vaccines 2022, 10, 1321. Buathong, R.; Hunsawong, T.; Wacharapluesadee, S.; Guharat, S.; Jirapipatt, R.; Ninwattana, S.; Thippamom, N.; Jitsatja, A.; Jones, A.R.; Rungrojchareonkit, K.; Lohachanakul, J.; Suthangkornkul, R.; Tayong, K.; Klungthong, C.; Fernandez, S.; Putcharoen, O. Homologous or Heterologous COVID-19 Booster Regimens Significantly Impact Sero-Neutralization of SARS-CoV-2 Virus and Its Variants. Vaccines 2022, 10, 1321.

Abstract

We determined the levels of neutralizing antibodies against the SARS-CoV-2 ancestral strain, Delta and Omicron variants of concern (VOCs) in 125 healthcare workers, who received Coro-naVac as their primary vaccination and later received either a single ChAdOx1 or a combination of two consecutive boosters using either two ChAdOx1 doses or a ChAdOx1 or BNT162b2 as the primary and second boosters, respectively, or 2 doses of BNT162b2. The titers 12 weeks after primary vaccination were inadequate to neutralize the all strains. After a single ChAdOx1 boost-er, the levels of neutralization at Day 30 varied significantly, only a small proportion of partici-pants developing neutralizing titers against Omicron at Day 7 and 30. The two doses of ChA-dOx1 as the booster induced lowest activity. A combination ChAdOx1 and BNT162b2 induced greater neutralization than by two doses of ChAdOx1. Two doses of BNT162b2 as the booster had the maximal activity against Omicron VOC.

Keywords

COVID-19; vaccine; booster; variants of concern; neutralization

Subject

Biology and Life Sciences, Immunology and Microbiology

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