Version 1
: Received: 5 August 2022 / Approved: 22 August 2022 / Online: 22 August 2022 (19:16:58 CEST)
How to cite:
White, K.; Wu, B.; Pilla, S. J.; Charleston, J.; Maw, M. T. T.; Appel, L. J.; Clark, J. M.; Maruthur, N. M. Design and Implementation of a Time-Restricted Feeding Intervention in a Randomized, Controlled Feeding Study. Preprints2022, 2022080388. https://doi.org/10.20944/preprints202208.0388.v1
White, K.; Wu, B.; Pilla, S. J.; Charleston, J.; Maw, M. T. T.; Appel, L. J.; Clark, J. M.; Maruthur, N. M. Design and Implementation of a Time-Restricted Feeding Intervention in a Randomized, Controlled Feeding Study. Preprints 2022, 2022080388. https://doi.org/10.20944/preprints202208.0388.v1
White, K.; Wu, B.; Pilla, S. J.; Charleston, J.; Maw, M. T. T.; Appel, L. J.; Clark, J. M.; Maruthur, N. M. Design and Implementation of a Time-Restricted Feeding Intervention in a Randomized, Controlled Feeding Study. Preprints2022, 2022080388. https://doi.org/10.20944/preprints202208.0388.v1
APA Style
White, K., Wu, B., Pilla, S. J., Charleston, J., Maw, M. T. T., Appel, L. J., Clark, J. M., & Maruthur, N. M. (2022). Design and Implementation of a Time-Restricted Feeding Intervention in a Randomized, Controlled Feeding Study. Preprints. https://doi.org/10.20944/preprints202208.0388.v1
Chicago/Turabian Style
White, K., Jeanne M Clark and Nisa M Maruthur. 2022 "Design and Implementation of a Time-Restricted Feeding Intervention in a Randomized, Controlled Feeding Study" Preprints. https://doi.org/10.20944/preprints202208.0388.v1
Abstract
The efficacy of time-restricted feeding for weight loss has not been established as prior studies were limited by lack of controlled isocaloric designs. This study describes the design and implementation of a controlled feeding study evaluating time-restricted feeding. We designed a randomized, controlled, parallel-arm, feeding study comparing time restricted feeding (TRF) to a usual feeding pattern (UFP) for the primary outcome of weight change. Participants were aged 18-69 years with prediabetes and obesity. TRF consumed 80% of calories by 1300, and UFP consumed ≥50% of calories after 1700. Both arms consumed identical macro- and micro-nutrients, based on a healthy palatable diet. We calculated individual calorie requirements which were maintained throughout the intervention. We randomized 41 participants who all completed the study. The desired distribution of calories across feeding windows in both arms was achieved, as were weekly averages for macronutrients and micronutrients. All randomized participants completed the study. We actively monitored participants and adapted diets to facilitate adherence. We provide the first report, to our knowledge, on the design and implementation of a feeding study that isolated the effect of meal timing on weight, while maintaining constant caloric intake and identical diets during the study period.
Keywords
time-restricted feeding; controlled feeding study; study design; nutrition interventions
Subject
Biology and Life Sciences, Food Science and Technology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.