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Last but not Least Important Variant: The Most Negative Gibbs Energy of Binding Indicates the Greatest Infectivity of the BA.2.75 Compared with Other SARS-CoV-2 Variants

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A peer-reviewed article of this preprint also exists.

Marko Popovic^*

This version is not peer-reviewed

This preprints belongs to the Topic

New Advances in Pathophysiology and Therapy of COVID-19 and Other Coronavirus Diseases

This preprints belongs to the Collection

Preprints on COVID-19 and SARS-CoV-2

Submitted:

20 September 2022

Posted:

21 September 2022

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Abstract

Omicron BA.2.75 may become the next globally dominant strain of COVID-19 in 2022. BA.2.75 sub-variant has acquired more mutations (9) in spike protein and other genes of SARS-CoV-2 than any other variant. Thus, its chemical composition and thermodynamic properties have changed comparing to earlier variants. In this paper Gibbs energy of binding and antigen-receptor binding rate is reported for the BA.2.75 variant. Gibbs energy of binding (driving force of binding) of Omicron BA.2.75 variant is more negative than that of the competing variants BA.2 and BA.5.

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Subject: Biology and Life Sciences - Virology

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