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Omicron BA.2.75 Sublineage Follows the Expectations of the Evolution Theory: Less Negative Gibbs Energy of Biosynthesis Indicates Decreased Pathogenicity
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New Advances in Pathophysiology and Therapy of COVID-19 and Other Coronavirus Diseases
Preprints on COVID-19 and SARS-CoV-2
Submitted:
25 October 2022
Posted:
25 October 2022
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Abstract
SARS-CoV-2 belongs to the group of RNA viruses with a pronounced tendency to mutate. Omicron BA.2.75 is a subvariant believed to be able to suppress the currently dominant BA.5. Omicron BA.2.75 is characterized by a greater infectivity compared to earlier Omicron variants. However, Gibbs energy of biosynthesis of virus particles is slightly less negative compared to those of other variants. Thus, the multiplication rate of Omicron BA.2.75 is lower than that of other variants. This leads to slower accumulation of newly formed virions and less damage to host cells, indicating evolution of SARS-CoV-2 towards decreasing pathogenicity.
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Subject: Biology and Life Sciences - Biophysics
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