Review
Version 1
Preserved in Portico This version is not peer-reviewed
Impact of Zinc on Insulin Resistance and Hepatic Fat Accumulation
Version 1
: Received: 29 December 2022 / Approved: 3 January 2023 / Online: 3 January 2023 (07:35:39 CET)
How to cite: Fatehi, M. Impact of Zinc on Insulin Resistance and Hepatic Fat Accumulation. Preprints 2023, 2023010012. https://doi.org/10.20944/preprints202301.0012.v1 Fatehi, M. Impact of Zinc on Insulin Resistance and Hepatic Fat Accumulation. Preprints 2023, 2023010012. https://doi.org/10.20944/preprints202301.0012.v1
Abstract
Insulin signaling plays a crucial role in cellular uptake of glucose and different metabolic pathways. Impairment in cellular insulin sensitivity due to various molecular pathways leads to Insulin resistance (IR) as well as fatty liver. In this review, mechanisms by which zinc involved in decreasing IR are described, focusing on oxidative stress, inflammation, immune system, gut flora and hepatic lipophagy. This study reviews the cause of IR and highlights the role of zinc in mechanisms diminishing IR and fatty liver.
Keywords
Insulin Resistance; Zinc supplementation; Oxidative stress; Inflammation; Gut microbiome; Hepatic lipophagy
Subject
Medicine and Pharmacology, Dentistry and Oral Surgery
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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