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Synthesis and Characterization of Abasic β-Diol-C-Nucleosides
Version 1
: Received: 11 April 2023 / Approved: 12 April 2023 / Online: 12 April 2023 (12:05:59 CEST)
A peer-reviewed article of this Preprint also exists.
Moccia, M.; Piras, L.; Bellini, G.; Saviano, M.; Adamo, M.F.A. Synthesis and Characterization of Abasic β-Diol-C-Nucleosides. Chemistry 2023, 5, 1343-1356. Moccia, M.; Piras, L.; Bellini, G.; Saviano, M.; Adamo, M.F.A. Synthesis and Characterization of Abasic β-Diol-C-Nucleosides. Chemistry 2023, 5, 1343-1356.
Abstract
Modified nucleobases are potentially useful building blocks when containing catalytically active functionalities and could be introduced in chiral tridimensional molecules such as nucleic acids, which creates the premises for the development of novel catalytic species. Herein we describe the synthesis of a novel β-C-nucleoside bearing a diol group at anomeric position, amenable as metal ligand or as organo-catalyst. The abasic ligand was successfully prepared and inserted into complementary DNA strand.
Keywords
C-nucleosides; abasic nucleosides; functionalized DNAs
Subject
Chemistry and Materials Science, Organic Chemistry
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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