Ahmed, J.; Faisal, M.; Algethami, J.S.; Alsaiari, M.A.; Alsareii, S.A.; Harraz, F.A. Low Overpotential Amperometric Sensor Using Yb2O3.CuO@rGO Nanocomposite for Sensitive Detection of Ascorbic Acid in Real Samples. Biosensors2023, 13, 588.
Ahmed, J.; Faisal, M.; Algethami, J.S.; Alsaiari, M.A.; Alsareii, S.A.; Harraz, F.A. Low Overpotential Amperometric Sensor Using Yb2O3.CuO@rGO Nanocomposite for Sensitive Detection of Ascorbic Acid in Real Samples. Biosensors 2023, 13, 588.
Ahmed, J.; Faisal, M.; Algethami, J.S.; Alsaiari, M.A.; Alsareii, S.A.; Harraz, F.A. Low Overpotential Amperometric Sensor Using Yb2O3.CuO@rGO Nanocomposite for Sensitive Detection of Ascorbic Acid in Real Samples. Biosensors2023, 13, 588.
Ahmed, J.; Faisal, M.; Algethami, J.S.; Alsaiari, M.A.; Alsareii, S.A.; Harraz, F.A. Low Overpotential Amperometric Sensor Using Yb2O3.CuO@rGO Nanocomposite for Sensitive Detection of Ascorbic Acid in Real Samples. Biosensors 2023, 13, 588.
Abstract
The ultimate objective of this research work is to design a sensitive and selective electrochemical sensor for efficient detection of ascorbic acid (AA), a vital antioxidant found in blood serum that may serve as a biomarker for oxidative stress. To achieve this, we utilized a novel Yb2O3.CuO@rGO nanocomposite (NC) as the active material to modify the glassy carbon working electrode (GCE). The structural properties and morphological characteristics of the Yb2O3.CuO@rGO NC were investigated using various techniques to ensure their suitability for the sensor. The resulting sensor electrode was able to detect a broad range of AA concentrations (0.5 - 1571 µM) in neutral phosphate buffer solution with a high sensitivity of 0.4341 µAµM-1cm-2 and a reasonable detection limit of 0.062 µM. The sensor's great sensitivity and selectivity allowed it to accurately determine the levels of AA in human blood serum and commercial vitamin C tablets. It demonstrated high levels of reproducibility, repeatability, and stability, making it a reliable and robust sensor for the measurement of AA at low overpotential. Overall, the Yb2O3.CuO@rGO/GCE sensor showed great potential in detecting AA from real samples.
Keywords
Ascorbic acid; Amperometric sensor; Yb2O3.CuO@rGO; Vitamin C; Human blood serum
Subject
Chemistry and Materials Science, Analytical Chemistry
Copyright:
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