Review
Version 1
Preserved in Portico This version is not peer-reviewed
Physiological Activity of Trace Element Germanium Including Anticancer Properties
Version 1
: Received: 27 April 2023 / Approved: 28 April 2023 / Online: 28 April 2023 (04:53:49 CEST)
A peer-reviewed article of this Preprint also exists.
Menchikov, L.G.; Popov, A.V. Physiological Activity of Trace Element Germanium Including Anticancer Properties. Biomedicines 2023, 11, 1535. Menchikov, L.G.; Popov, A.V. Physiological Activity of Trace Element Germanium Including Anticancer Properties. Biomedicines 2023, 11, 1535.
Abstract
Germanium is an essential microelement, and its deficiency can result in numerous diseases, particularly oncogenic conditions. Consequently, water-soluble germanium compounds, including inorganic and coordination compounds, have attracted significant attention due to their biological activity. The review analyzes the primary research from the last decade related to the anticancer activity of germanium compounds. Furthermore, the review clarifies their actual toxicity, identifies errors and misconceptions that have contributed to the discrediting of their biological activity, and suggests a putative mechanism of germanium-mediated protection from oxidative stress. Finally, the review provides clarifications on the discovery history of water-soluble organic germanium compounds, which was distorted and hushed up for a long time.
Keywords
germanium compounds; Ge-132; germatrane; biological activity; cancer; Warburg effect
Subject
Medicine and Pharmacology, Pharmacology and Toxicology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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