The objective of this study was to compare the effect of different botanical powders and synthetic chemical in controlling Sitophilus zeamais in stored maize. A laboratory experiment was done to assess three botanicals, Zingiber officinale, Moringa oleifera, Xylopia aethiopica, in controlling the S. zeamais. The results of this study demonstrated the active potentials of these plant products as plant-derived insecticides against maize weevil. The synthetic chemical used showed both higher weevil mortality and higher grain loss than the botanicals (P< 0.05). The Botanicals also showed significance difference in the mortality rate (P < 0.05) as Z. officinale recorded the highest mortality rate (5.66%) while X. aethiopica recorded the lowest mortality rate (3.66%). The control attained the highest grain damage (7.33%) while amongst the botanicals, the highest was found in Z. officinale (7.33%) and lowest was on M. oliefera (5.33%). The exit holes made by the weevils at the end of the experiment were highest (2.66) in M. oliefera whereas lowest was recorded on X. aethiopica (1.00). Z. officinale, X. aethiopica and M. oleifera were efficacious against S. zeamais instead of synthetic chemical insecticides that have environmental health hazards and they can be used in integrated pest management by farmers and foods merchants. Therefore, since these botanicals have no any adverse effects on the seeds and safe to the environment, they are recommended for future usage in storage grains to control of S. zeamais.