Exercise Effects on Left Ventricular Remodeling in Patients With Cardiometabolic Risk Factors

Evanthia Bletsa; Evangelos Oikonomou; Kyriakos Dimitriadis; Panagiota K. Stampouloglou; Christos Fragoulis; Stavroula P. Lontou; Emmanouil Korakas; Eirini Beneki; Konstantinos Kalogeras; Vaia Lampadiari; Konstantinos Tsioufis; Manolis Vavouranakis; Gerasimos Siasos

doi:10.20944/preprints202306.0991.v1

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preprints.org > medicine and pharmacology > cardiac and cardiovascular systems > doi: 10.20944/preprints202306.0991.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Exercise Effects on Left Ventricular Remodeling in Patients With Cardiometabolic Risk Factors

Evanthia Bletsa

Evangelos Oikonomou

^* ,

Kyriakos Dimitriadis

Panagiota K. Stampouloglou

Konstantinos Kalogeras

Vaia Lampadiari

Konstantinos Tsioufis

Manolis Vavouranakis

Gerasimos Siasos

Version 1 : Received: 13 June 2023 / Approved: 14 June 2023 / Online: 14 June 2023 (05:34:21 CEST)

A peer-reviewed article of this Preprint also exists.

Bletsa, E.; Oikonomou, E.; Dimitriadis, K.; Stampouloglou, P.K.; Fragoulis, C.; Lontou, S.P.; Korakas, E.; Beneki, E.; Kalogeras, K.; Lambadiari, V.; Tsioufis, K.; Vavouranakis, M.; Siasos, G. Exercise Effects on Left Ventricular Remodeling in Patients with Cardiometabolic Risk Factors. Life 2023, 13, 1742. Bletsa, E.; Oikonomou, E.; Dimitriadis, K.; Stampouloglou, P.K.; Fragoulis, C.; Lontou, S.P.; Korakas, E.; Beneki, E.; Kalogeras, K.; Lambadiari, V.; Tsioufis, K.; Vavouranakis, M.; Siasos, G. Exercise Effects on Left Ventricular Remodeling in Patients with Cardiometabolic Risk Factors. Life 2023, 13, 1742.

Abstract

Left ventricular (LV) remodeling is a dynamic process which is characterized by abnormal LV wall thickness and altered myocardial geometry, and it is considered as a negative prognostic factor in both heart failure with reduced eject fraction (HFrEF) and heart failure with preserved eject fraction (HFpEF). Hypertension, type 2 diabetes (T2D) and obesity are strongly correlated with the development and the progression of LV remodeling, LV hypertrophy and LV systolic and/or diastolic dysfunction. Indeed, the beneficial impact of exercise training on primary and secondary prevention of cardiovascular disease (CVD) has been well-established. Recent studies highlight that exercise training enhances functional capacity, muscle strength and endurance, cardiac function and cardiac-related biomarkers, among patients with established coronary artery disease (CAD) or HF, thus improving substantially their cardiovascular prognosis, survival rates and needs for rehospitalization. Therefore, in this review article, we discuss the evidence of LV remodeling in patients with cardiometabolic risk factors, such as hypertension, T2D, obesity, and also highlight the current studies evaluating the effect of exercise training on LV remodeling in these patients.

Keywords

exercise; diabetes; obesity; hypertension; ventricular remodeling; heart failure

Subject

Medicine and Pharmacology, Cardiac and Cardiovascular Systems

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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