Review
Version 2
Preserved in Portico This version is not peer-reviewed
The Neglected Sibling: NLRP2 Inflammasome in the Nervous System
Version 1
: Received: 3 July 2023 / Approved: 4 July 2023 / Online: 4 July 2023 (07:27:56 CEST)
Version 2 : Received: 11 November 2023 / Approved: 14 November 2023 / Online: 14 November 2023 (11:31:07 CET)
Version 2 : Received: 11 November 2023 / Approved: 14 November 2023 / Online: 14 November 2023 (11:31:07 CET)
A peer-reviewed article of this Preprint also exists.
László Ducza , Botond Gaál. The Neglected Sibling: NLRP2 Inflammasome in the Nervous System. Aging and disease. 2023 https://doi.org/10.14336/AD.2023.0926-1 László Ducza , Botond Gaál. The Neglected Sibling: NLRP2 Inflammasome in the Nervous System. Aging and disease. 2023 https://doi.org/10.14336/AD.2023.0926-1
Abstract
While classical NOD-like receptor pyrin domain containing protein 1 (NLRP1) and NLRP3 inflammasomal proteins have been extensively investigated, the contribution of NLRP2 is still ill-defined in the nervous system. Given the putative significance of NLRP2 in orchestrating neuroinflammation, further inquiry is needed to gain a better understanding of its connectome, hence its specific targeting may hold a promising therapeutic implication. Therefore, bioinformatical approach for extracting information, specifically in the context of neuropathologies, is also undoubtedly preferred. To the best of our knowledge, there is no review study selectively targeting only NLRP2. Increasing, but still fragmentary evidence should encourage researchers to thoroughly investigate this inflammasome in various animal- and human models. Taken together, herein we aimed to review the current literature focusing on the role of NLRP2 inflammasome in the nervous system and more importantly, we provide an algorythm-based protein network of human NLRP2 for elucidating potentially valuable molecular partnerships.
Keywords
inflammasome; NLRP2; neurological disorders; connectome; STRING
Subject
Medicine and Pharmacology, Neuroscience and Neurology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Commenter: Laszlo Ducza
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