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A peer-reviewed article of this preprint also exists.
This version is not peer-reviewed
Characteristic | Controls | CAD patients | P |
---|---|---|---|
(n=427) | (n=424) | ||
Male (n, %) | 153 (35.8) | 153 (36.1) | 0.375 |
Age (years, mean ± SD) | 61.44±11.52 | 62.55±10.26 | 0.136 |
Hypertension (n, %) | 171 (40.0) | 226 (57.4) | <0.0001 |
Diabetes mellitus (n, %) | 51 (11.9) | 119 (30.2) | <0.0001 |
Hyperlipidemia (n, %) | 97 (22.7) | 116 (29.4) | 0.028 |
Smoking (n, %) | 136 (31.9) | 101 (25.6) | 0.049 |
Body mass index (kg/cm2, mean ± SD) | 24.26±3.34 | 25.21±3.12 | <0.001 |
Fasting blood sugar (mg/dL, mean ± SD) | 111.98±33.93 | 141.23±63.78 | <0.001 |
HbA1c (%, mean ± SD) | 6.08±1.16 | 6.67±2.99 | 0.048 |
HDL-C (mg/dl, mean ± SD) | 47.02±13.90 | 43.83±11.58 | 0.005 |
LDL-C (mg/dl, mean ± SD) | 121.31±43.32 | 111.87±38.20 | 0.012 |
Total cholesterol (mg/dl, mean ± SD) | 194.02±38.14 | 185.98±45.06 | 0.006 |
Triglyceride (mg/dl, mean ± SD) | 142.16±86.73 | 155.52±97.04 | 0.037 |
Hcy (μmol/L, mean ± SD) | 9.77±3.91 | 9.92±5.09 | 0.620 |
Folate (nmol/L, mean ± SD) | 9.14±7.94 | 8.69±9.73 | 0.467 |
Genotypes | Controls | CAD | AOR (95% CI)* | Pa | FDR-P |
---|---|---|---|---|---|
(n=427) | (n=424) | ||||
TSER | |||||
3R3R | 296 (69.3) | 301 (71.0) | 1.000 (reference) | ||
2R3R | 123 (28.8) | 115 (27.1) | 0.934 (0.677-1.288) | 0.676 | 0.676 |
2R2R | 8 (1.9) | 8 (1.9) | 1.139 (0.401-3.236) | 0.807 | 0.807 |
Additive model | 0.964 (0.725-1.281) | 0.800 | 0.800 | ||
Dominant model | 0.945 (0.691-1.293) | 0.724 | 0.724 | ||
Recessive model | 1.141 (0.398-3.271) | 0.806 | 0.826 | ||
HWE-P | 0.240 | 0.431 | |||
TS 1100T>C | |||||
TT | 217 (50.8) | 194 (45.8) | 1.000 (reference) | ||
TC | 177 (41.5) | 189 (44.6) | 1.333 (0.989-1.798) | 0.060 | 0.240 |
CC | 33 (7.7) | 41 (9.7) | 1.344 (0.786-2.298) | 0.281 | 0.562 |
Additive model | 1.249 (1.000-1.562) | 0.050 | 0.100 | ||
Dominant model | 1.350 (1.014-1.797) | 0.040 | 0.158 | ||
Recessive model | 1.230 (0.738-2.052) | 0.427 | 0.826 | ||
HWE-P | 0.709 | 0.607 | |||
TS 1170A>G | |||||
AA | 211 (49.4) | 234 (55.2) | 1.000 (reference) | ||
AG | 183 (42.9) | 172 (40.6) | 0.832 (0.618-1.121) | 0.227 | 0.454 |
GG | 33 (7.7) | 18 (4.2) | 0.464 (0.242-0.889) | 0.021 | 0.084 |
Additive model | 0.763 (0.602-0.966) | 0.025 | 0.100 | ||
Dominant model | 0.773 (0.580-1.030) | 0.079 | 0.158 | ||
Recessive model | 0.532 (0.288-0.983) | 0.044 | 0.176 | ||
HWE-P | 0.439 | 0.084 | |||
TS 1494ins/del | |||||
0bp0bp | 195 (45.7) | 211 (49.8) | 1.000 (reference) | ||
0bp6bp | 193 (45.2) | 174 (41.0) | 0.907 (0.673-1.223) | 0.522 | 0.676 |
6bp6bp | 39 (9.1) | 39 (9.2) | 0.878 (0.521-1.480) | 0.625 | 0.807 |
Additive model | 0.934 (0.749-1.164) | 0.542 | 0.723 | ||
Dominant model | 0.908 (0.683-1.208) | 0.508 | 0.677 | ||
Recessive model | 0.946 (0.574-1.557) | 0.826 | 0.826 | ||
HWE-P | 0.372 | 0.717 |
Haplotype | Control (2n=854) | CAD (2n=848) | OR (95% CI) | Pa | FDR-P |
---|---|---|---|---|---|
TSER/TS1100/1170/1494 | |||||
3R-T-A-0bp | 0.3554 | 0.3916 | 1.000 (reference) | ||
3R-T-G-0bp | 0.2780 | 0.2133 | 0.699 (0.546-0.896) | 0.006 | 0.039 |
3R-C-A-0bp | 0.0024 | 0.0512 | 19.690 (4.727-81.990) | <0.0001 | 0.001 |
TSER/TS1100/1170 | |||||
3R-T-A | 0.3781 | 0.4148 | 1.000 (Reference) | ||
3R-T-G | 0.2794 | 0.2132 | 0.695 (0.544 - 0.888) | 0.003 | 0.021 |
2R-T-A | 0.048 | 0.0307 | 0.582 (0.348 - 0.973) | 0.033 | 0.116 |
TSER/TS1100/1494 | |||||
3R-T-0bp | 0.6336 | 0.6049 | 1.000 (Reference) | ||
3R-C-0bp | 0.0037 | 0.0550 | 16.522 (5.110 - 53.414) | <0.0001 | 0.001 |
TSER/TS1170/1494 | |||||
3R-A-0bp | 0.3592 | 0.4487 | 1.000 (Reference) | ||
3R-A-6bp | 0.1965 | 0.1792 | 0.731 (0.560 - 0.954) | 0.021 | 0.053 |
3R-G-0bp | 0.2782 | 0.2109 | 0.608 (0.475 - 0.777) | <0.0001 | 0.001 |
2R-A-0bp | 0.0355 | 0.0231 | 0.539 (0.300 - 0.967) | 0.033 | 0.053 |
2R-A-6bp | 0.1173 | 0.1037 | 0.711 (0.514 - 0.983) | 0.038 | 0.053 |
2R-G-6bp | 0.0002 | 0.0075 | 10.51 (0.589 - 187.400) | 0.037 | 0.053 |
TS1100/1170/1494 | |||||
T-A-0bp | 0.392 | 0.4153 | 1.000 (Reference) | ||
T-G-0bp | 0.287 | 0.2326 | 0.765 (0.602 - 0.973) | 0.028 | 0.098 |
C-A-0bp | 0.0024 | 0.0509 | 20.462 (4.918 - 85.133) | <0.0001 | 0.001 |
TSER/TS 1170 | |||||
3R-A | 0.5578 | 0.6302 | 1.000 (Reference) | ||
3R-G | 0.2794 | 0.2153 | 0.683 (0.543 - 0.858) | 0.001 | 0.003 |
2R-A | 0.1506 | 0.1245 | 0.732 (0.551 - 0.974) | 0.031 | 0.031 |
2R-G | 0.0122 | 0.0300 | 2.228 (1.059 - 4.688) | 0.017 | 0.026 |
TS 1100/1170 | |||||
T-A | 0.4259 | 0.4452 | 1.000 (Reference) | ||
T-G | 0.2896 | 0.2353 | 0.780 (0.616 - 0.987) | 0.038 | 0.057 |
C-G | 0.0020 | 0.0100 | 3.852 (0.813 - 18.261) | 0.023 | 0.057 |
TS 1100/1494 | |||||
T-0bp | 0.6790 | 0.6478 | 1.000 (Reference) | ||
C-0bp | 0.0037 | 0.0550 | 16.551 (5.122 - 53.488) | <0.0001 | 0.0003 |
TS 1170/1494 | |||||
A-0bp | 0.3949 | 0.4715 | 1.000 (Reference) | ||
A-6bp | 0.3135 | 0.2832 | 0.754 (0.602 - 0.946) | 0.015 | 0.015 |
G-0bp | 0.2878 | 0.2313 | 0.671 (0.530 - 0.851) | 0.001 | 0.003 |
G-6bp | 0.0038 | 0.0140 | 3.370 (0.943 - 12.042) | 0.014 | 0.015 |
Genotype combinations | Controls | CAD | AOR (95% CI) | P* |
---|---|---|---|---|
(n=427) | (n=424) | |||
TSER/TS 1170A>G | ||||
3R3R/AA | 130 (30.4) | 164 (38.7) | 1.000 (reference) | |
3R3R/AG | 136 (31.9) | 122 (28.8) | 0.656 (0.461 - 0.934) | 0.020 |
3R3R/GG | 30 (7.0) | 15 (3.5) | 0.335 (0.162 - 0.691) | 0.003 |
2R3R/AA | 74 (17.3) | 65 (15.3) | 0.634 (0.405 - 0.990) | 0.045 |
TS 1100T>C/TS 1170A>G | ||||
TT/AA | 70 (16.4) | 86 (20.3) | 1.000 (reference) | |
TT/AG | 114 (26.7) | 92 (21.7) | 0.593 (0.376 - 0.936) | 0.025 |
TT/GG | 33 (7.7) | 16 (3.8) | 0.330 (0.153 - 0.708) | 0.004 |
TS 1100T>C/TS 1494ins>del | ||||
TT/0bp0bp | 194 (45.4) | 180 (42.5) | 1.000 (reference) | |
TC/0bp0bp | 1 (0.2) | 21 (5.0) | 26.713 (3.462 - 206.115) | 0.002 |
TS 1170A>G/TS 1494ins>del | ||||
AA/0bp0bp | 57 (13.3) | 101 (23.8) | 1.000 (reference) | |
AA/0bp6bp | 117 (27.4) | 97 (22.9) | 0.479 (0.303 - 0.755) | 0.002 |
AA/6bp6bp | 37 (8.7) | 36 (8.5) | 0.454 (0.241 - 0.857) | 0.015 |
AG/0bp0bp | 105 (24.6) | 94 (22.2) | 0.463 (0.292 - 0.734) | 0.001 |
AG/0bp6bp | 76 (17.8) | 75 (17.7) | 0.539 (0.331 - 0.876) | 0.013 |
GG/0bp0bp | 33 (7.7) | 16 (3.8) | 0.213 (0.098 - 0.462) | 0.0001 |
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. |
supplementary.zip (255.35KB )
Submitted:
11 July 2023
Posted:
12 July 2023
You are already at the latest version
A peer-reviewed article of this preprint also exists.
supplementary.zip (255.35KB )
This version is not peer-reviewed
Submitted:
11 July 2023
Posted:
12 July 2023
You are already at the latest version
Characteristic | Controls | CAD patients | P |
---|---|---|---|
(n=427) | (n=424) | ||
Male (n, %) | 153 (35.8) | 153 (36.1) | 0.375 |
Age (years, mean ± SD) | 61.44±11.52 | 62.55±10.26 | 0.136 |
Hypertension (n, %) | 171 (40.0) | 226 (57.4) | <0.0001 |
Diabetes mellitus (n, %) | 51 (11.9) | 119 (30.2) | <0.0001 |
Hyperlipidemia (n, %) | 97 (22.7) | 116 (29.4) | 0.028 |
Smoking (n, %) | 136 (31.9) | 101 (25.6) | 0.049 |
Body mass index (kg/cm2, mean ± SD) | 24.26±3.34 | 25.21±3.12 | <0.001 |
Fasting blood sugar (mg/dL, mean ± SD) | 111.98±33.93 | 141.23±63.78 | <0.001 |
HbA1c (%, mean ± SD) | 6.08±1.16 | 6.67±2.99 | 0.048 |
HDL-C (mg/dl, mean ± SD) | 47.02±13.90 | 43.83±11.58 | 0.005 |
LDL-C (mg/dl, mean ± SD) | 121.31±43.32 | 111.87±38.20 | 0.012 |
Total cholesterol (mg/dl, mean ± SD) | 194.02±38.14 | 185.98±45.06 | 0.006 |
Triglyceride (mg/dl, mean ± SD) | 142.16±86.73 | 155.52±97.04 | 0.037 |
Hcy (μmol/L, mean ± SD) | 9.77±3.91 | 9.92±5.09 | 0.620 |
Folate (nmol/L, mean ± SD) | 9.14±7.94 | 8.69±9.73 | 0.467 |
Genotypes | Controls | CAD | AOR (95% CI)* | Pa | FDR-P |
---|---|---|---|---|---|
(n=427) | (n=424) | ||||
TSER | |||||
3R3R | 296 (69.3) | 301 (71.0) | 1.000 (reference) | ||
2R3R | 123 (28.8) | 115 (27.1) | 0.934 (0.677-1.288) | 0.676 | 0.676 |
2R2R | 8 (1.9) | 8 (1.9) | 1.139 (0.401-3.236) | 0.807 | 0.807 |
Additive model | 0.964 (0.725-1.281) | 0.800 | 0.800 | ||
Dominant model | 0.945 (0.691-1.293) | 0.724 | 0.724 | ||
Recessive model | 1.141 (0.398-3.271) | 0.806 | 0.826 | ||
HWE-P | 0.240 | 0.431 | |||
TS 1100T>C | |||||
TT | 217 (50.8) | 194 (45.8) | 1.000 (reference) | ||
TC | 177 (41.5) | 189 (44.6) | 1.333 (0.989-1.798) | 0.060 | 0.240 |
CC | 33 (7.7) | 41 (9.7) | 1.344 (0.786-2.298) | 0.281 | 0.562 |
Additive model | 1.249 (1.000-1.562) | 0.050 | 0.100 | ||
Dominant model | 1.350 (1.014-1.797) | 0.040 | 0.158 | ||
Recessive model | 1.230 (0.738-2.052) | 0.427 | 0.826 | ||
HWE-P | 0.709 | 0.607 | |||
TS 1170A>G | |||||
AA | 211 (49.4) | 234 (55.2) | 1.000 (reference) | ||
AG | 183 (42.9) | 172 (40.6) | 0.832 (0.618-1.121) | 0.227 | 0.454 |
GG | 33 (7.7) | 18 (4.2) | 0.464 (0.242-0.889) | 0.021 | 0.084 |
Additive model | 0.763 (0.602-0.966) | 0.025 | 0.100 | ||
Dominant model | 0.773 (0.580-1.030) | 0.079 | 0.158 | ||
Recessive model | 0.532 (0.288-0.983) | 0.044 | 0.176 | ||
HWE-P | 0.439 | 0.084 | |||
TS 1494ins/del | |||||
0bp0bp | 195 (45.7) | 211 (49.8) | 1.000 (reference) | ||
0bp6bp | 193 (45.2) | 174 (41.0) | 0.907 (0.673-1.223) | 0.522 | 0.676 |
6bp6bp | 39 (9.1) | 39 (9.2) | 0.878 (0.521-1.480) | 0.625 | 0.807 |
Additive model | 0.934 (0.749-1.164) | 0.542 | 0.723 | ||
Dominant model | 0.908 (0.683-1.208) | 0.508 | 0.677 | ||
Recessive model | 0.946 (0.574-1.557) | 0.826 | 0.826 | ||
HWE-P | 0.372 | 0.717 |
Haplotype | Control (2n=854) | CAD (2n=848) | OR (95% CI) | Pa | FDR-P |
---|---|---|---|---|---|
TSER/TS1100/1170/1494 | |||||
3R-T-A-0bp | 0.3554 | 0.3916 | 1.000 (reference) | ||
3R-T-G-0bp | 0.2780 | 0.2133 | 0.699 (0.546-0.896) | 0.006 | 0.039 |
3R-C-A-0bp | 0.0024 | 0.0512 | 19.690 (4.727-81.990) | <0.0001 | 0.001 |
TSER/TS1100/1170 | |||||
3R-T-A | 0.3781 | 0.4148 | 1.000 (Reference) | ||
3R-T-G | 0.2794 | 0.2132 | 0.695 (0.544 - 0.888) | 0.003 | 0.021 |
2R-T-A | 0.048 | 0.0307 | 0.582 (0.348 - 0.973) | 0.033 | 0.116 |
TSER/TS1100/1494 | |||||
3R-T-0bp | 0.6336 | 0.6049 | 1.000 (Reference) | ||
3R-C-0bp | 0.0037 | 0.0550 | 16.522 (5.110 - 53.414) | <0.0001 | 0.001 |
TSER/TS1170/1494 | |||||
3R-A-0bp | 0.3592 | 0.4487 | 1.000 (Reference) | ||
3R-A-6bp | 0.1965 | 0.1792 | 0.731 (0.560 - 0.954) | 0.021 | 0.053 |
3R-G-0bp | 0.2782 | 0.2109 | 0.608 (0.475 - 0.777) | <0.0001 | 0.001 |
2R-A-0bp | 0.0355 | 0.0231 | 0.539 (0.300 - 0.967) | 0.033 | 0.053 |
2R-A-6bp | 0.1173 | 0.1037 | 0.711 (0.514 - 0.983) | 0.038 | 0.053 |
2R-G-6bp | 0.0002 | 0.0075 | 10.51 (0.589 - 187.400) | 0.037 | 0.053 |
TS1100/1170/1494 | |||||
T-A-0bp | 0.392 | 0.4153 | 1.000 (Reference) | ||
T-G-0bp | 0.287 | 0.2326 | 0.765 (0.602 - 0.973) | 0.028 | 0.098 |
C-A-0bp | 0.0024 | 0.0509 | 20.462 (4.918 - 85.133) | <0.0001 | 0.001 |
TSER/TS 1170 | |||||
3R-A | 0.5578 | 0.6302 | 1.000 (Reference) | ||
3R-G | 0.2794 | 0.2153 | 0.683 (0.543 - 0.858) | 0.001 | 0.003 |
2R-A | 0.1506 | 0.1245 | 0.732 (0.551 - 0.974) | 0.031 | 0.031 |
2R-G | 0.0122 | 0.0300 | 2.228 (1.059 - 4.688) | 0.017 | 0.026 |
TS 1100/1170 | |||||
T-A | 0.4259 | 0.4452 | 1.000 (Reference) | ||
T-G | 0.2896 | 0.2353 | 0.780 (0.616 - 0.987) | 0.038 | 0.057 |
C-G | 0.0020 | 0.0100 | 3.852 (0.813 - 18.261) | 0.023 | 0.057 |
TS 1100/1494 | |||||
T-0bp | 0.6790 | 0.6478 | 1.000 (Reference) | ||
C-0bp | 0.0037 | 0.0550 | 16.551 (5.122 - 53.488) | <0.0001 | 0.0003 |
TS 1170/1494 | |||||
A-0bp | 0.3949 | 0.4715 | 1.000 (Reference) | ||
A-6bp | 0.3135 | 0.2832 | 0.754 (0.602 - 0.946) | 0.015 | 0.015 |
G-0bp | 0.2878 | 0.2313 | 0.671 (0.530 - 0.851) | 0.001 | 0.003 |
G-6bp | 0.0038 | 0.0140 | 3.370 (0.943 - 12.042) | 0.014 | 0.015 |
Genotype combinations | Controls | CAD | AOR (95% CI) | P* |
---|---|---|---|---|
(n=427) | (n=424) | |||
TSER/TS 1170A>G | ||||
3R3R/AA | 130 (30.4) | 164 (38.7) | 1.000 (reference) | |
3R3R/AG | 136 (31.9) | 122 (28.8) | 0.656 (0.461 - 0.934) | 0.020 |
3R3R/GG | 30 (7.0) | 15 (3.5) | 0.335 (0.162 - 0.691) | 0.003 |
2R3R/AA | 74 (17.3) | 65 (15.3) | 0.634 (0.405 - 0.990) | 0.045 |
TS 1100T>C/TS 1170A>G | ||||
TT/AA | 70 (16.4) | 86 (20.3) | 1.000 (reference) | |
TT/AG | 114 (26.7) | 92 (21.7) | 0.593 (0.376 - 0.936) | 0.025 |
TT/GG | 33 (7.7) | 16 (3.8) | 0.330 (0.153 - 0.708) | 0.004 |
TS 1100T>C/TS 1494ins>del | ||||
TT/0bp0bp | 194 (45.4) | 180 (42.5) | 1.000 (reference) | |
TC/0bp0bp | 1 (0.2) | 21 (5.0) | 26.713 (3.462 - 206.115) | 0.002 |
TS 1170A>G/TS 1494ins>del | ||||
AA/0bp0bp | 57 (13.3) | 101 (23.8) | 1.000 (reference) | |
AA/0bp6bp | 117 (27.4) | 97 (22.9) | 0.479 (0.303 - 0.755) | 0.002 |
AA/6bp6bp | 37 (8.7) | 36 (8.5) | 0.454 (0.241 - 0.857) | 0.015 |
AG/0bp0bp | 105 (24.6) | 94 (22.2) | 0.463 (0.292 - 0.734) | 0.001 |
AG/0bp6bp | 76 (17.8) | 75 (17.7) | 0.539 (0.331 - 0.876) | 0.013 |
GG/0bp0bp | 33 (7.7) | 16 (3.8) | 0.213 (0.098 - 0.462) | 0.0001 |
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. |
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