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Arboviral Risk Associated with Solid Organ and Hematopoietic Stem Cell Grafts: The Prophylactic Answers Proposed by the French High Council of Public Health in a National Context
Pozzetto, B.; Grard, G.; Durand, G.; Paty, M.-C.; Gallian, P.; Lucas-Samuel, S.; Diéterlé, S.; Fromage, M.; Durand, M.; Lepelletier, D.; Chidiac, C.; Hoen, B.; Nicolas de Lamballerie, X. Arboviral Risk Associated with Solid Organ and Hematopoietic Stem Cell Grafts: The Prophylactic Answers Proposed by the French High Council of Public Health in a National Context. Viruses2023, 15, 1783.
Pozzetto, B.; Grard, G.; Durand, G.; Paty, M.-C.; Gallian, P.; Lucas-Samuel, S.; Diéterlé, S.; Fromage, M.; Durand, M.; Lepelletier, D.; Chidiac, C.; Hoen, B.; Nicolas de Lamballerie, X. Arboviral Risk Associated with Solid Organ and Hematopoietic Stem Cell Grafts: The Prophylactic Answers Proposed by the French High Council of Public Health in a National Context. Viruses 2023, 15, 1783.
Pozzetto, B.; Grard, G.; Durand, G.; Paty, M.-C.; Gallian, P.; Lucas-Samuel, S.; Diéterlé, S.; Fromage, M.; Durand, M.; Lepelletier, D.; Chidiac, C.; Hoen, B.; Nicolas de Lamballerie, X. Arboviral Risk Associated with Solid Organ and Hematopoietic Stem Cell Grafts: The Prophylactic Answers Proposed by the French High Council of Public Health in a National Context. Viruses2023, 15, 1783.
Pozzetto, B.; Grard, G.; Durand, G.; Paty, M.-C.; Gallian, P.; Lucas-Samuel, S.; Diéterlé, S.; Fromage, M.; Durand, M.; Lepelletier, D.; Chidiac, C.; Hoen, B.; Nicolas de Lamballerie, X. Arboviral Risk Associated with Solid Organ and Hematopoietic Stem Cell Grafts: The Prophylactic Answers Proposed by the French High Council of Public Health in a National Context. Viruses 2023, 15, 1783.
Abstract
Diseases caused by arboviruses are on the increase worldwide. In addition to arthropod bites, most arboviruses can be transmitted via accessory routes. Products of human origin (labile blood products, solid organs, hematopoietic stem cells, tissues) present a risk of contamination for the recipient if the donation is made when the donor is viremic. This narrative review describes the risks of acquiring certain arboviral diseases from human products, mainly solid organs and hematopoietic stem cells, in the French context. Mainland France and its overseas territories are exposed to a complex array of imported and endemic arboviruses, which differ according to their respective location. The main risks considered in this study are infections by West Nile virus, dengue virus and tick-borne encephalitis virus. The ancillary risks represented by Usutu virus infection, chikungunya and Zika are also addressed more briefly. For each disease, the guidelines issued by the French High Council of Public Health, which is responsible for issuing guidelines to mitigate the risks associated with products of human origin and for supporting public health policy decisions, are briefly outlined. The aim of this review is also to contribute to the standardization of recommendations at international level in areas with the same viral epidemiology.
Keywords
safety of products of human origin; solid organ transplantation; hematopoietic stem-cell transplantation; West Nile virus; dengue virus; tick-borne encephalitis virus; Usutu virus; Chikungunya virus; Zika virus; mainland and overseas France
Subject
Biology and Life Sciences, Virology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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