3. Results
The first research question asked about the frequency in the chronic pain status groups among children aged 6 -17 years in the United States. The estimated prevalence of chronic pain was 4.0% and chronic pain plus was 3.9% with typical peers making up 92.1%.
The second research question asked what the sociodemographic characteristics were among children aged 6 -17 years across chronic pain status groups. Demographics for the sample and results of tests of association are in
Table 1. A larger percentage of both the chronic pain and chronic pain plus groups were female than male. Across all three chronic pain status groups, a larger percentage were aged between 12 and 17 years. A majority of the sample across all three pain status groups were White, non-Hispanic. Tests of association between chronic pain status and demographic variables were conducted. Hypotheses were that there would be significant associations such that decreasing severity of chronic pain condition status (i.e., chronic pain plus, chronic pain, typical peers) would be associated with younger age, being male, being White, higher socioeconomic status, higher parental education, and greater health insurance status. There were significant associations between chronic pain status and all demographic variables, in expected directions.
Additional tests of association between chronic pain condition status, using only the chronic pain plus and chronic pain categories of the variable, and demographic variables also were conducted. This was potentially important because it could differentiate these two rarely studied groups. Again, hypotheses were that there would be significant associations such that decreasing severity of chronic pain condition status (i.e., chronic pain plus, chronic pain) would be associated with being male, higher socioeconomic status, higher parental education, and greater health insurance status. Results were significant, in the hypothesized direction, and a weak association for sex, χ2 (2484) = 17.54, p < .001, Cramer’s V = .08; poverty level, τb (2484) = .06, p = .001; parental education; τb (2484) = .04, p = .04; and health insurance status, χ2 (2459) = 64.1605, p < .001, Cramer’s V = .16; but not significant for age, race/ethnicity, and working poor. Of note, the chronic pain plus group was significantly less female (51.8%) than the pain group (60.1%).
The third research question was whether there was an association between chronic pain condition status and flourishing in children aged 6-17 years. The hypothesis was that there would be a significant association such that as chronic pain condition status is less severe, flourishing increases.
Figure 1 shows flourishing across the three chronic pain status groups. There was a significant moderate association between chronic pain condition status and flourishing, τb (31405) = .249, p < .001, which indicates that this association is likely in the population. There was also a significant moderate association between chronic pain condition status and the two-level version of flourishing, τb (31405) = .237, p < .001.
Overall flourishing was made up of three items, and the association of chronic pain condition status and each item of flourishing were significant in the expected direction: shows interest and curiosity in learning new things, τb (31354) = -.145, p < .001, a weak association; works to finish the tasks they start, τb (30936) = -.177, p < .001, a weak association; and stays calm and in control when faced with a challenge, τb (31196) = -.207, p < .001, a moderate association. When examining only the chronic pain plus and chronic pain categories of the chronic pain status group variable, the association of chronic pain condition status and each item of flourishing also were significant in the expected direction: shows interest and curiosity in learning new things, τb (2477) = -.25, p < .001, a moderate association; works to finish the tasks they start, τb (2454) = -.35, p < .001, a strong association; and stays calm and in control when faced with a challenge, τb (2468) = -.41, p < .001, a strong association.
The fourth research question was whether chronic pain condition status would add significant incremental predictive utility in the prediction of flourishing over and above a block of demographic predictors. The hypothesis was that chronic pain condition status would provide significant incremental predictive utility over and above a block of demographic predictors. Hierarchical binary logistic regression was used to evaluate a model for predicting flourishing. The model was composed of two blocks of predictors. The first block of predictors consisted of age, sex, race/ethnicity, poverty level, parental education, and health insurance status. Chronic pain condition status constituted the second block of predictors.
Initial assumptions of logistic regression (independence of observations, categories of outcome variable and categorical predictor variables mutually exclusive and exhaustive, sufficient ratio of cases per predictor variable [here > 3000:1]) were met. To assess multicollinearity among the predictors, all of which are categorical, the predictor variables were dummy coded, and multiple linear regression was run with these dummy variables to generate VIF and tolerance values. Dummy variables associated with some categories of the poverty level (tolerance = .23, VIF = 4.39) and working poor families (tolerance = .28, VIF =3.53) variables indicated that these two variables had a potentially problematic degree of multicollinearity. For all other predictor variables, tolerance was > .2 and VIF was < 1.6, indicating an absence of significant multicollinearity. After removing the working poor variable, tolerance was > .6 and VIF was < 1.7 for all predictor variables. Thus, the logistic regression analysis was repeated after excluding the working poor variable. As to the absence of outliers, leverage points, or highly influential points, 285 of 30893 cases (0.92%) had a standardized residual value > 2.5, with 4 of those cases having a standardized residual value > 3.0. This was deemed to be a negligible portion of the sample; thus, the assumption was met.
Results of the hierarchical logistic regression are provided in
Table 2. As expected, both the initial model, which consisted of the first block of predictors (age, sex, race/ethnicity, poverty level, parental education, and health insurance status), χ2 = 1153.13, p < .001, and the full model, which consisted of the first and second block of predictors (chronic pain condition status), χ2 = 2846.85, p = .000, significantly outperformed the null model. The Hosmer and Lemeshow test indicated that both the initial, χ2 = 7.40, p = .49, and full model, χ2 = 12.94, p =.11, fit the data appropriately. In addition, a pseudo R2 measure, used in logistic regression as a means to determine the goodness of fit of a model, yielded Nagelkerke pseudo R2 =.054 for the initial model and Nagelkerke pseudo R2 = .131 for the full model. This indicates that the full model better predicted flourishing than the initial model.
As expected, sex, age, race/ethnicity, poverty level, parental education, and health insurance status were all significant predictors of flourishing in the full model. Looking at the odds ratios for pairwise comparisons for demographic predictors in the full model, most were significant with a few exceptions. For the race/ethnicity variable, comparisons between White and Black (p = .757) and White and other/multi-racial, non-Hispanic (p = .145) were not significant. For health insurance status, the comparison between being uninsured and having both private and public health insurance (p = .280) was not significant.
As expected, the second block of predictors (chronic pain condition status) provided significant incremental utility in predicting flourishing, χ2 = 1693.72, p < .001). In other words, adding chronic pain condition status to the initial model increased the ability of the full model to predict flourishing over and above the other predictors. Classification statistics for both the initial and full models are provided in
Table 3 and
Table 4. The addition of the chronic pain condition status marginally increased classification accuracy over the initial model from 75.4% to 77.8%.
Overall, chronic pain condition status significantly predicted flourishing, Wald χ2 = 1379.61, p < .001. Using the reciprocal of the odds ratios (and their confidence intervals) from
Table 2, the odds of not flourishing for children with chronic pain is 2.33 times greater than for typical peers (OR = 2.33, 95% CI, 2.05 to 2.63). Of particular note, the odds of not flourishing for children with chronic pain and comorbidities is 13 times greater than for typical peers (OR = 12.99, 95% CI: 11.24 to 14.93).
4. Discussion
Using secondary data analysis of a nationally representative sample of American children between 6 and 17 years with chronic pain (determined by parent report of chronic pain with functional impairments during the last 12 months), we found that chronic pain was strongly associated with reduced flourishing. Moreover, we found that for those children and adolescents living with chronic pain plus an emotional, developmental, or behavioral comorbidity there was an even stronger association with reduced flourishing over and above what was found for children who experienced chronic pain without comorbidities. Specifically, children with chronic pain were 2.33 times less likely to flourish than typical peers, and children with chronic pain plus an emotional, developmental, or behavioral comorbidity were 13 times less likely to flourish than their typical peers. Ultimately, these results suggest that while chronic pain alone is problematic for flourishing, children and adolescents who also live with an emotional, developmental, or behavioral comorbidity have a much greater risk of not flourishing. These results are not only consistent with our hypotheses, but they are also consistent with the findings of prior studies on both chronic pain and flourishing and chronic pain plus comorbidities and flourishing [
15,
18,
19].
From a nationally representative dataset, chronic pain occurred in 4.0% of our sample and the prevalence of chronic pain plus comorbidities was 3.9%. The overall chronic pain prevalence (7.9%) fell toward the lower end of the large prevalence range (6% - 57%) identified in the existing literature base [
8,
22]. However, in this study, we identified children and adolescents with chronic pain through parent endorsement of the criteria “this child had frequent or chronic difficulty with repeated or chronic physical pain, including headaches or other back or body pain” over the past 12 months plus parent report of at least one special health need (e.g., use or need of prescription medication; above average use or need of medical, mental health or educational services; functional limitations compared with others of the same age that is not mental health related). This allowed us to identify children who were functionally limited by their chronic pain and/or required the help of professional services. To identify those with comorbidities, parent response to the question “Does this child have any kind of emotional, developmental, or behavioral problem for which he or she needs treatment or counseling?” was used in addition to the chronic pain criteria outlined above. This was a different approach to identifying children and adolescents with chronic pain who were functionally limited by their chronic pain, with comparable studies identifying participants with chronic pain exclusively by parental report of chronic pain in the last 12 months. Therefore, our more nuanced and stringent inclusion criteria may be the reason our overall prevalence rate was lower than that reported in other studies [
22].
Identifying and managing chronic pain and associated comorbidities is extremely important in both the short and long term. In addition to pain-related functional impairment, poorer social, emotional, physical, and socioeconomic outcomes are more likely to be experienced by those who experience chronic pain during childhood than typical peers [
2,
3,
13]. These negative outcomes not only burden the individuals but their families, immediate communities, and the greater population. Therefore, healthcare systems must work to reduce chronic pain and the commonly associated emotional, developmental, or behavioral comorbidities. Moreover, given the potentially more deleterious outcomes for those with chronic pain and comorbidities as identified by this study and other recent similar studies, resources are needed to evaluate and treat chronic pain effectively in pediatric populations [
23]. The even greater risk of not flourishing for those in the chronic pain and comorbidities group identified by the results of this study underscores the need for more consistent screening that considers mental health, as well as resiliency factors, in pediatric patients. All too often, screenings are focused exclusively on medical factors or current pain status and fail to consider other needs.
The developmental systems theory underpinned this study, as both chronic pain and flourishing are complex and multidimensional with several factors playing an important role in their relationship [
21]. Looking at the sociodemographic variables included in the model (age, sex, race/ethnicity, poverty level, parental education, and health insurance status), there was a significant association between chronic pain condition status and demographic variables. Looking only at the chronic pain plus and chronic pain groups, results were significant for sex, poverty level, parental education, and health insurance status but not for age, race/ethnicity, and working poor. While many of these demographic characteristics are consistent with previous research related to risk and resiliency, it is important for practitioners to uniquely consider parental education and gender [
24]. Notably, as seen in previous literature, those in the chronic pain group were more likely to be female (60.1%) than male (39.9%), however, the chronic pain plus group did not have such a substantial sex disparity, with males and females each representing close to 50%. This is an important finding for practitioners as male children tend to be overlooked relative to emotional screening [
25,
26].
4.1. Implications
The results of the study highlight a clear need for practitioners to improve universal screening of pediatric chronic pain and common mental health comorbidities. By accurately identifying the children and adolescents who are impacted by chronic pain, interventions can be focused not only on reducing negative outcomes but also on promoting positive outcomes like flourishing. Moreover, when assessing pediatric pain, those with mental health comorbidities must be identified, as traditional chronic pain treatments may not be sufficient to help facilitate positive outcomes for this population. Healthcare professionals need to be educated regarding the fact that chronic pain treatments may not be as successful if they do not consider mental health comorbidities. The uniqueness of those with chronic pain plus an emotional, developmental, or behavioral comorbidity highlighted in the results also underscores the need for the development of specific interventions that target chronic pain as well as mental health comorbidities in pediatric populations.
The results also emphasize the need for more evidence-based interventions specifically targeted at low-income, low-education families. Given the negative outcomes that can occur later in life if chronic pain is not addressed during childhood, it is particularly important that healthcare professionals who work with the populations who are most impacted, as well as parents, caregivers, and teachers in these communities, are educated about how to identify and treat chronic pain [
4]. Education programs must be mindful of those children whose parents have a lower level of education though, and they must consider how to make psychoeducation accessible and subsequently impactful to all children living with chronic pain.
4.2. Limitations
The findings of this study should be assessed with the following limitations in mind. Firstly, chronic pain was identified exclusively by parent responses to two questions based exclusively on the child’s health and behavior over the last 12 months. While this allowed us to identify children and adolescents who were experiencing chronic pain that was impacting their functioning or requiring medical attention, this was a more specific criteria than what has been used by comparable studies which resulted in a smaller reported prevalence. Moreover, given the cross-sectional study design, it is not possible to infer a causal pathway between chronic pain condition status and flourishing. This relationship may be bidirectional, with a lack of flourishing leading to chronic pain and emotional, developmental, and behavioral comorbidities.