Yu, Y.H.; Kim, S.-W.; Im, H.; Lee, Y.R.; Kim, G.W.; Ryu, S.; Park, D.-K.; Kim, D.-S. Febrile Seizure Causes Deficit in Social Novelty, Gliosis, and Proinflammatory Cytokine Response in the Hippocampal CA2 Region in Rats. Cells2023, 12, 2446.
Yu, Y.H.; Kim, S.-W.; Im, H.; Lee, Y.R.; Kim, G.W.; Ryu, S.; Park, D.-K.; Kim, D.-S. Febrile Seizure Causes Deficit in Social Novelty, Gliosis, and Proinflammatory Cytokine Response in the Hippocampal CA2 Region in Rats. Cells 2023, 12, 2446.
Yu, Y.H.; Kim, S.-W.; Im, H.; Lee, Y.R.; Kim, G.W.; Ryu, S.; Park, D.-K.; Kim, D.-S. Febrile Seizure Causes Deficit in Social Novelty, Gliosis, and Proinflammatory Cytokine Response in the Hippocampal CA2 Region in Rats. Cells2023, 12, 2446.
Yu, Y.H.; Kim, S.-W.; Im, H.; Lee, Y.R.; Kim, G.W.; Ryu, S.; Park, D.-K.; Kim, D.-S. Febrile Seizure Causes Deficit in Social Novelty, Gliosis, and Proinflammatory Cytokine Response in the Hippocampal CA2 Region in Rats. Cells 2023, 12, 2446.
Abstract
Febrile seizure (FS), which occurs as a response to fever, is the most common seizure that occurs in infants and young children. FS is usually accompanied by diverse neuropsychiatric symptoms including impaired social behaviors; however, no causative link between FS and autism spectrum disorder (ASD) has yet been established. Here, we provide evidence linking FS occurrence with ASD pathogenesis in rats. We developed an FS juvenile rats model and found ASD-like abnormal behaviors including deficits in social novelty, repetitive behaviors, and hyperlocomotion. In addition, FS model juvenile rats showed enhanced levels of gliosis and inflammation in the hippocampal CA2 region and cerebellum. Furthermore, abnormal levels of social and repetitive behaviors persisted in adults FS model rats. These findings suggest that occurrence of FS in infants can cause behavioral endophenotypes of ASD.
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.