Review
Version 2
Preserved in Portico This version is not peer-reviewed
Non-invasive Multiregional Tumor Sampling Using Magnetic Nanoparticle-Loaded Macrophages
Version 1
: Received: 21 August 2023 / Approved: 21 August 2023 / Online: 22 August 2023 (07:58:07 CEST)
Version 2 : Received: 5 September 2023 / Approved: 6 September 2023 / Online: 7 September 2023 (02:54:00 CEST)
Version 3 : Received: 31 December 2023 / Approved: 2 January 2024 / Online: 2 January 2024 (10:00:17 CET)
Version 4 : Received: 4 February 2024 / Approved: 5 February 2024 / Online: 5 February 2024 (13:52:59 CET)
Version 5 : Received: 21 March 2024 / Approved: 22 March 2024 / Online: 22 March 2024 (12:06:13 CET)
Version 6 : Received: 9 May 2024 / Approved: 9 May 2024 / Online: 9 May 2024 (10:33:03 CEST)
Version 7 : Received: 7 June 2024 / Approved: 7 June 2024 / Online: 7 June 2024 (14:31:49 CEST)
Version 8 : Received: 26 June 2024 / Approved: 27 June 2024 / Online: 1 July 2024 (09:27:29 CEST)
Version 9 : Received: 5 August 2024 / Approved: 6 August 2024 / Online: 7 August 2024 (09:30:23 CEST)
Version 2 : Received: 5 September 2023 / Approved: 6 September 2023 / Online: 7 September 2023 (02:54:00 CEST)
Version 3 : Received: 31 December 2023 / Approved: 2 January 2024 / Online: 2 January 2024 (10:00:17 CET)
Version 4 : Received: 4 February 2024 / Approved: 5 February 2024 / Online: 5 February 2024 (13:52:59 CET)
Version 5 : Received: 21 March 2024 / Approved: 22 March 2024 / Online: 22 March 2024 (12:06:13 CET)
Version 6 : Received: 9 May 2024 / Approved: 9 May 2024 / Online: 9 May 2024 (10:33:03 CEST)
Version 7 : Received: 7 June 2024 / Approved: 7 June 2024 / Online: 7 June 2024 (14:31:49 CEST)
Version 8 : Received: 26 June 2024 / Approved: 27 June 2024 / Online: 1 July 2024 (09:27:29 CEST)
Version 9 : Received: 5 August 2024 / Approved: 6 August 2024 / Online: 7 August 2024 (09:30:23 CEST)
How to cite: Renteln, M. Non-invasive Multiregional Tumor Sampling Using Magnetic Nanoparticle-Loaded Macrophages. Preprints 2023, 2023081536. https://doi.org/10.20944/preprints202308.1536.v2 Renteln, M. Non-invasive Multiregional Tumor Sampling Using Magnetic Nanoparticle-Loaded Macrophages. Preprints 2023, 2023081536. https://doi.org/10.20944/preprints202308.1536.v2
Abstract
Some tumors occur in anatomical regions that are hard to biopsy with a needle. Such regions include the brain, spinal cord, liver, and lungs. For the latter two, magnetic nanoparticle-loaded macrophages could be intravenously infused and driven via an MRI machine into the tumor or tumors. Once there, they can be induced to phagocytose whole tumor cells. They would keep their target in a non-digested form by inhibiting phagosome maturation - and be directed via magnetotaxis or chemotaxis to an extraction point in the body where they can be more easily collected via needle.
Keywords
Multiregional sequencing; multi-sample sequencing; targeted cancer therapy; OVERCOME; macrophage magnetotaxis
Subject
Medicine and Pharmacology, Oncology and Oncogenics
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Commenter: Michael Renteln
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