A New Paradigm in Cancer Treatment: Identifying and Targeting Clonal Mutations

Michael Renteln

doi:10.20944/preprints202308.1536.v6

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preprints.org > medicine and pharmacology > oncology and oncogenics > doi: 10.20944/preprints202308.1536.v6

Preprint Review Version 6 Preserved in Portico This version is not peer-reviewed

A New Paradigm in Cancer Treatment: Identifying and Targeting Clonal Mutations

Michael Renteln

Version 1 : Received: 21 August 2023 / Approved: 21 August 2023 / Online: 22 August 2023 (07:58:07 CEST)
Version 2 : Received: 5 September 2023 / Approved: 6 September 2023 / Online: 7 September 2023 (02:54:00 CEST)
Version 3 : Received: 31 December 2023 / Approved: 2 January 2024 / Online: 2 January 2024 (10:00:17 CET)
Version 4 : Received: 4 February 2024 / Approved: 5 February 2024 / Online: 5 February 2024 (13:52:59 CET)
Version 5 : Received: 21 March 2024 / Approved: 22 March 2024 / Online: 22 March 2024 (12:06:13 CET)
Version 6 : Received: 9 May 2024 / Approved: 9 May 2024 / Online: 9 May 2024 (10:33:03 CEST)

How to cite: Renteln, M. A New Paradigm in Cancer Treatment: Identifying and Targeting Clonal Mutations. Preprints 2023, 2023081536. https://doi.org/10.20944/preprints202308.1536.v6 Renteln, M. A New Paradigm in Cancer Treatment: Identifying and Targeting Clonal Mutations. Preprints 2023, 2023081536. https://doi.org/10.20944/preprints202308.1536.v6

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MDPI and ACS Style

Renteln, M. A New Paradigm in Cancer Treatment: Identifying and Targeting Clonal Mutations. Preprints 2023, 2023081536. https://doi.org/10.20944/preprints202308.1536.v6

APA Style

Renteln, M. (2024). A New Paradigm in Cancer Treatment: Identifying and Targeting Clonal Mutations. Preprints. https://doi.org/10.20944/preprints202308.1536.v6

Chicago/Turabian Style

Renteln, M. 2024 "A New Paradigm in Cancer Treatment: Identifying and Targeting Clonal Mutations" Preprints. https://doi.org/10.20944/preprints202308.1536.v6

Abstract

Recently concluded, large-scale cancer genomics studies involving multiregion sequencing of primary tumors and paired metastases appear to indicate that many or most cancer patients have one or more “clonal" mutations in their tumors. Clonal mutations are those that are present in all of a patient’s cancer cells. Achilles Therapeutics is currently the only company specifically targeting clonal mutations. However, they are doing so with tumor-derived T cells. To address the potential limitations of immunotherapy, I have devised another approach for exploiting clonal mutations, which I call “Oncolytic Vector Efficient Replication Contingent on Omnipresent Mutation Engagement” (OVERCOME). The ideal version of OVERCOME would likely employ a bioengineered facultative intracellular bacterium. The bacterium would initially be attenuated, but (transiently) reverse its attenuation upon clonal mutation detection.

Keywords

multiregion sequencing; multisample sequencing; cell-free circulating tumor DNA; clonal mutations; Achilles Therapeutics; OVERCOME

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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