Review
Version 1
Preserved in Portico This version is not peer-reviewed
Various Biomimetics as Antifungals
Version 1
: Received: 25 August 2023 / Approved: 28 August 2023 / Online: 28 August 2023 (09:44:34 CEST)
A peer-reviewed article of this Preprint also exists.
Efremenko, E.; Aslanli, A.; Stepanov, N.; Senko, O.; Maslova, O. Various Biomimetics, Including Peptides as Antifungals. Biomimetics 2023, 8, 513. Efremenko, E.; Aslanli, A.; Stepanov, N.; Senko, O.; Maslova, O. Various Biomimetics, Including Peptides as Antifungals. Biomimetics 2023, 8, 513.
Abstract
Biomimetics, which are similar to natural compounds that play an important role in the metabolism, manifestation of functional activity and reproduction of various fungi, have a pronounced attrac-tion in the current search for new effective antifungals. Actual trends in the development of this area of research indicate that unnatural amino acids can be used as such biomimetics, including those containing halogen atoms; compounds similar to nitrogenous bases embedded in the nucleic acids synthesized by fungi; peptides imitating fungal analogues; molecules similar to natural sub-strates of numerous fungal enzymes and Quorum Sensing signaling molecules of fungi and yeast; etc. Most part of the review is devoted to the analysis of semi-synthetic and synthetic antifungal peptides and their targets of action. This review is aimed at combining and systematizing the cur-rent scientific information accumulating in this area of research, developing various antifungals with an assessment of the effectiveness of the created biomimetics and the possibility of combining them with other antimicrobial substances to reduce cell resistance and improve antifungal effects.
Keywords
antifungal peptides; enzyme-like activity; growth inhibition; antifungal activity; fungal metabolites; quorum response molecules; combined antifungals
Subject
Biology and Life Sciences, Life Sciences
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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