Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Nitric Oxide as a Determinant of Human Longevity and Health Span

Version 1 : Received: 1 September 2023 / Approved: 4 September 2023 / Online: 6 September 2023 (14:47:08 CEST)

A peer-reviewed article of this Preprint also exists.

Poeggeler, B.; Singh, S.K.; Sambamurti, K.; Pappolla, M.A. Nitric Oxide as a Determinant of Human Longevity and Health Span. Int. J. Mol. Sci. 2023, 24, 14533. Poeggeler, B.; Singh, S.K.; Sambamurti, K.; Pappolla, M.A. Nitric Oxide as a Determinant of Human Longevity and Health Span. Int. J. Mol. Sci. 2023, 24, 14533.

Abstract

The master molecular regulators and mechanisms determining longevity and health span include nitric oxide (NO) and superoxide anion radicals (SOR). L-arginine, the NO synthase (NOS) substrate, can restore a healthy ratio between the dangerous SOR and the protective NO radical to promote healthy aging. Antioxidant supplementation orchestrates protection against oxidative stress and damage—L-arginine and antioxidants such as vitamin C increase NO production and bioavailability. Uncoupling of NO generation with the appearance of SOR can be induced by asymmetric dimethylarginine (ADMA). L-arginine can displace ADMA from the site of NO formation if sufficient amounts of the amino acid are available. Antioxidants such as ascorbic acids can scavenge SOR and increase the bioavailability of NO. The topics of this review are the complex interactions of antioxidant agents with L-arginine, which determine NO bioactivity and protection against age-related degeneration.

Keywords

aging; amino acids; antioxidant; arginine; nitric oxide; oxidative stress; protein; peptide

Subject

Biology and Life Sciences, Aging

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