Wences Chirino, T.; Rangel López, E.; Luna Angulo, A.; Carrillo Mora, P.; Landa Solis, C.; Samudio Cruz, M.A.; Fuentes Bello, A.C.; Paniagua Pérez, R.; Ríos Martínez, J.; Sánchez Chapul, L. Crosstalk between Exercise-Derived Endocannabinoidome and Kynurenines: Potential Target Therapies for Obesity and Depression Symptoms. Pharmaceuticals2023, 16, 1421.
Wences Chirino, T.; Rangel López, E.; Luna Angulo, A.; Carrillo Mora, P.; Landa Solis, C.; Samudio Cruz, M.A.; Fuentes Bello, A.C.; Paniagua Pérez, R.; Ríos Martínez, J.; Sánchez Chapul, L. Crosstalk between Exercise-Derived Endocannabinoidome and Kynurenines: Potential Target Therapies for Obesity and Depression Symptoms. Pharmaceuticals 2023, 16, 1421.
Wences Chirino, T.; Rangel López, E.; Luna Angulo, A.; Carrillo Mora, P.; Landa Solis, C.; Samudio Cruz, M.A.; Fuentes Bello, A.C.; Paniagua Pérez, R.; Ríos Martínez, J.; Sánchez Chapul, L. Crosstalk between Exercise-Derived Endocannabinoidome and Kynurenines: Potential Target Therapies for Obesity and Depression Symptoms. Pharmaceuticals2023, 16, 1421.
Wences Chirino, T.; Rangel López, E.; Luna Angulo, A.; Carrillo Mora, P.; Landa Solis, C.; Samudio Cruz, M.A.; Fuentes Bello, A.C.; Paniagua Pérez, R.; Ríos Martínez, J.; Sánchez Chapul, L. Crosstalk between Exercise-Derived Endocannabinoidome and Kynurenines: Potential Target Therapies for Obesity and Depression Symptoms. Pharmaceuticals 2023, 16, 1421.
Abstract
The kynurenine pathway (KP) and the endocannabinoid system (ECS) are known to be deregulated in depression and obesity; however, it has been recognized that acute physical exercise has an important modulating role inducing changes in the mobilization of their respective metabolites -endocannabinoids (eCB) and kynurenines (KYN)- which overlap at some points, acting as im-portant antidepressant, anti-nociceptive, anti-inflammatory, and antioxidant biomarkers. There-fore, the aim of this review is to analyze and discuss some studies performed recently to investigate the potential interactions between both systems, particularly, those related with exercise-derived endocannabinoidome and kynurenine mechanisms and to elucidate how, the prescription of physical exercise could represent a new approach for the clinical manage of these two conditions.
Public Health and Healthcare, Physical Therapy, Sports Therapy and Rehabilitation
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