Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Epitranscriptomics as a New Layer of Regulation of Gene Expression in Skeletal Muscle: Known Functions and Future Perspectives

Version 1 : Received: 17 September 2023 / Approved: 18 September 2023 / Online: 19 September 2023 (03:43:06 CEST)

A peer-reviewed article of this Preprint also exists.

Imbriano, C.; Moresi, V.; Belluti, S.; Renzini, A.; Cavioli, G.; Maretti, E.; Molinari, S. Epitranscriptomics as a New Layer of Regulation of Gene Expression in Skeletal Muscle: Known Functions and Future Perspectives. Int. J. Mol. Sci. 2023, 24, 15161. Imbriano, C.; Moresi, V.; Belluti, S.; Renzini, A.; Cavioli, G.; Maretti, E.; Molinari, S. Epitranscriptomics as a New Layer of Regulation of Gene Expression in Skeletal Muscle: Known Functions and Future Perspectives. Int. J. Mol. Sci. 2023, 24, 15161.

Abstract

Epitranscriptomics refers to post-transcriptional regulation of gene expression via RNA modifications and editing that affect RNA functions. Many kinds of modifications of mRNA have been described, among which N6-Methyladenosine (m6A), N1-methyladenosine (m1A), 7-methylguanosine (m7G), pseudouridine (Ψ), 5-methylcytidine (m5C). They alter mRNA structure and consequently stability, localization and translation efficiency. Perturbation of the epitranscriptome is associated with human diseases, thus opening the opportunity for potential manipulations as therapeutic approach. In this review, we overview the functional roles of epitranscriptomic marks in the skeletal muscle system, in particular in embryonic myogenesis, muscle cell differentiation and muscle homeostasis processes. Further, we explored high throughput epitranscriptome sequencing data to identify RNA chemical modifications in muscle-specific genes and we discuss the possible functional role and the potential therapeutic applications.

Keywords

epitranscriptomics; RNA modifications; m6A; skeletal muscle; gene expression

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

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