Version 1
: Received: 25 September 2023 / Approved: 26 September 2023 / Online: 26 September 2023 (07:15:04 CEST)
How to cite:
Ugwu, C.; Lin, P.; Laliotis, G. Histone H3K36 and H3K27 Modifiers and Readers as Prognostic Factors in Patients with Cancer—A Pancancer Analysis. Preprints2023, 2023091740. https://doi.org/10.20944/preprints202309.1740.v1
Ugwu, C.; Lin, P.; Laliotis, G. Histone H3K36 and H3K27 Modifiers and Readers as Prognostic Factors in Patients with Cancer—A Pancancer Analysis. Preprints 2023, 2023091740. https://doi.org/10.20944/preprints202309.1740.v1
Ugwu, C.; Lin, P.; Laliotis, G. Histone H3K36 and H3K27 Modifiers and Readers as Prognostic Factors in Patients with Cancer—A Pancancer Analysis. Preprints2023, 2023091740. https://doi.org/10.20944/preprints202309.1740.v1
APA Style
Ugwu, C., Lin, P., & Laliotis, G. (2023). Histone H3K36 and H3K27 Modifiers and Readers as Prognostic Factors in Patients with Cancer—A Pancancer Analysis. Preprints. https://doi.org/10.20944/preprints202309.1740.v1
Chicago/Turabian Style
Ugwu, C., Pauline Lin and George Laliotis. 2023 "Histone H3K36 and H3K27 Modifiers and Readers as Prognostic Factors in Patients with Cancer—A Pancancer Analysis" Preprints. https://doi.org/10.20944/preprints202309.1740.v1
Abstract
Histone modifications, especially H3K27 and H3K36 methylations, are crucial for epigenetic regulation and are often dysregulated in cancer. In a comprehensive analysis of 11,194 patient samples across 32 cancer types, we identified significant genomic alterations in H3K27 and H3K36 modifiers, with the most common being in KDM6B, BRPF1, KDM6A, SETD2, and NSD1. Patients with these alterations also frequently exhibited mutations in genes like TP53 and PIK3CA. Moreover, the presence of these histone modifier alterations correlated with poorer overall survival, emphasizing their potential as both oncogenic drivers and prognostic markers in various cancers.
Keywords
Histone Modifiers; cancer; Genomics;
Subject
Biology and Life Sciences, Biology and Biotechnology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.