Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

DNA damage response & senescence-associated secretory phenotype pathway: Emerging targets for anti-aging

Version 1 : Received: 27 September 2023 / Approved: 28 September 2023 / Online: 28 September 2023 (04:56:53 CEST)

How to cite: Nadeem, J.; Parveen, A.; Kim, S. Y. DNA damage response & senescence-associated secretory phenotype pathway: Emerging targets for anti-aging. Preprints 2023, 2023091932. https://doi.org/10.20944/preprints202309.1932.v1 Nadeem, J.; Parveen, A.; Kim, S. Y. DNA damage response & senescence-associated secretory phenotype pathway: Emerging targets for anti-aging. Preprints 2023, 2023091932. https://doi.org/10.20944/preprints202309.1932.v1

Abstract

Cellular aging has drawn the attention of researchers, scientists, and biotech businesses for the treatment of a number of medical conditions. Cellular aging is primarily defined by consistent cessation of proliferative development in response to internal and external stressors, including DNA damage, telomere shortening, mitochondrial dysfunction, and regulation of the senescence-associated secretory phenotype (SASP). Disturbances involving these factors may contribute to age-related disease development. Therefore, the current review aims to explore anti-aging factors targeting DNA damage response and SASP regulation and their detailed signaling networks. In addition, it provides an opportunity for researchers to identify not only anti-aging targets, but also anti-aging therapeutic strategies based on identified and non-identified targets.

Keywords

Anti-aging, DNA damage response, senescence-associated secretory phenotype

Subject

Medicine and Pharmacology, Medicine and Pharmacology

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