Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Modulatory Bioeffects of Pomegranate (Punica granatum L.) Polyphenols on Metabolic Disorders: Understanding their Preventive Role against Metabolic Syndrome

Version 1 : Received: 1 October 2023 / Approved: 1 October 2023 / Online: 1 October 2023 (08:42:27 CEST)

A peer-reviewed article of this Preprint also exists.

Alami, M.; Boumezough, K.; Khalil, A.; Ramchoun, M.; Boulbaroud, S.; Fulop, T.; Morvaridzadeh, M.; Berrougui, H. The Modulatory Bioeffects of Pomegranate (Punica granatum L.) Polyphenols on Metabolic Disorders: Understanding Their Preventive Role against Metabolic Syndrome. Nutrients 2023, 15, 4879. Alami, M.; Boumezough, K.; Khalil, A.; Ramchoun, M.; Boulbaroud, S.; Fulop, T.; Morvaridzadeh, M.; Berrougui, H. The Modulatory Bioeffects of Pomegranate (Punica granatum L.) Polyphenols on Metabolic Disorders: Understanding Their Preventive Role against Metabolic Syndrome. Nutrients 2023, 15, 4879.

Abstract

Modern research achievements support health-promoting effects of natural products and diets rich in polyphenols. Pomegranate (PG) (Punica granatum L.) contain a considerable number of bioactive compounds that exert a broad spectrum of beneficial biological activities, including antimicrobial, antidiabetic, antiobesity, and atheroprotective properties. In this view, the reviewed literature shows that PG intake might reduce insulin resistance, cytokine levels, redox gene expression, blood pressure elevation, vascular injuries and lipoprotein oxidative modifications. Lipid parameters corrective capabilities of PG-ellagitannins are also sufficiently reported to be significantly effective in reducing hyperlipidemia (TC, LDL-C, VLDL-C, and TAGs), plasma HDL-C concentrations, TC/HDL-C and LDL-C/HDL-C ratio. The health benevolent effects of pomegranate consumption appear to be produced through the amelioration of adipose tissue endocrine function, fatty acid utilization, GLUT receptor expression, paraoxonase activity enhancement, PPAR and NFκB modulation. Although the results from animal experiments are encouraging, human findings published in this field are inconsistent and still limited in many points of view. The present review discusses and provides a critical analysis of PG's bioeffects on metabolic syndrome components, type-2 diabetes, obesity, and dyslipidemia, as well as on some cardiovascular-related diseases. A brief overview of the pharmacokinetic properties, safety, and bioavailability of PG-ellagitannins is also included.

Keywords

Punica granatum L.; pharmacokinetic; metabolic disorders; dyslipidaemia

Subject

Biology and Life Sciences, Life Sciences

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