Review
Version 1
Preserved in Portico This version is not peer-reviewed
A Mechanistic Discussion on Oxidative Stress and Ferroptosis
Version 1
: Received: 22 October 2023 / Approved: 23 October 2023 / Online: 23 October 2023 (09:42:29 CEST)
How to cite: Mukherjee, S.; Munshi, C. A Mechanistic Discussion on Oxidative Stress and Ferroptosis. Preprints 2023, 2023101423. https://doi.org/10.20944/preprints202310.1423.v1 Mukherjee, S.; Munshi, C. A Mechanistic Discussion on Oxidative Stress and Ferroptosis. Preprints 2023, 2023101423. https://doi.org/10.20944/preprints202310.1423.v1
Abstract
Ferroptosis is a recent form of non-apoptotic cell death, which occurs due to imbalance of iron homeostasis (iron overload). Oxidative stress due to the impairment of the antioxidant system is a major pathophysiology during ferroptosis, which eventually results in lipid peroxidation. The cellular and physiological biomarker of ferroptotic cell death includes major alteration in the glutathione peroxidase 4 (GPX4) antioxidant system and lipid peroxidation induced loss of plasma membrane integrity. This review elaborates the mechanism of oxidative stress which triggers ferroptosis.
Keywords
Oxidative stress; Ferroptosis; Iron; Cell death; Lipid peroxidation
Subject
Biology and Life Sciences, Cell and Developmental Biology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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