Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Revolutionizing the Management of Large-Core Ischaemic Strokes: Decoding the Success of Endovascular Therapy in the Recent Stroke Trials

Version 1 : Received: 13 November 2023 / Approved: 13 November 2023 / Online: 14 November 2023 (05:23:27 CET)

A peer-reviewed article of this Preprint also exists.

Lim, G.Z.; Lai, J.Y.; Seet, C.Y.H.; Tham, C.H.; Venketasubramanian, N.; Tan, B.Y.Q.; Jing, M.; Yeo, J.Y.P.; Myint, M.Z.; Sia, C.-H.; Teoh, H.L.; Sharma, V.K.; Chan, B.P.L.; Yang, C.; Makmur, A.; Ong, S.J.; Yeo, L.L.L. Revolutionizing the Management of Large-Core Ischaemic Strokes: Decoding the Success of Endovascular Therapy in the Recent Stroke Trials. J. Cardiovasc. Dev. Dis. 2023, 10, 499. Lim, G.Z.; Lai, J.Y.; Seet, C.Y.H.; Tham, C.H.; Venketasubramanian, N.; Tan, B.Y.Q.; Jing, M.; Yeo, J.Y.P.; Myint, M.Z.; Sia, C.-H.; Teoh, H.L.; Sharma, V.K.; Chan, B.P.L.; Yang, C.; Makmur, A.; Ong, S.J.; Yeo, L.L.L. Revolutionizing the Management of Large-Core Ischaemic Strokes: Decoding the Success of Endovascular Therapy in the Recent Stroke Trials. J. Cardiovasc. Dev. Dis. 2023, 10, 499.

Abstract

Endovascular therapy (EVT) has revolutionized the management of acute ischaemic strokes with large vessel occlusion, with emerging evidence suggesting its benefit also in large infarct core volume strokes. In the last 2 years, 4 randomised controlled trials have been published on this topic - RES-CUE-Japan-LIMIT, ANGEL-ASPECT, SELECT2 and TENSION, with overall results showing that EVT improves functional and neurological outcomes compared to medical management alone. This review seeks to summarise the recent evidence presented by these 4 trials and highlight some of the limitations of our current understanding on this topic.

Keywords

ischaemic stroke; endovascular treatment; radiology; CT; MRI; acute; large in-farcts

Subject

Medicine and Pharmacology, Neuroscience and Neurology

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